Human NPM1/B23/NPM ORF/cDNA clone-Adenovirus plasmid (BC002398)

Cat. No.: pGMAP000065
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human NPM1/B23/NPM adenoviral expression plasmid for NPM1 adenovirus packaging, NPM1 adenovirus.

Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.

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Product Description

Catalog ID pGMAP000065
Gene Name NPM1
Accession Number BC002398
Gene ID 4869
Species Human
Product Type Adenovirus plasmid (overexpression)
Insert Length 885 bp
Gene Alias B23,NPM
Fluorescent Reporter GFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Kanamycin
ORF Nucleotide Sequence ATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGGTTGTGAACTAAAGGCCGACAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGAACGGTCAGTTTAGGGGCTGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAATGAATTACGAAGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAAAATGTCTGTACAGCCAACGGTTTCCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCATATTAGTGGACAGCACTTAGTAGCTGTGGAGGAAGATGCAGAGTCAGAAGATGAAGAGGAGGAGGATGTGAAACTCTTAAGTATATCTGGAAAGCGGTCTGCCCCTGGAGGTGGTAGCAAGGTTCCACAGAAAAAAGTAAAACTTGCTGCTGATGAAGATGATGACGATGATGATGAAGAGGATGATGATGAAGATGATGATGATGATGATTTTGATGATGAGGAAGCTGAAGAAAAAGCGCCAGTGAAGAAATCTATACGAGATACTCCAGCCAAAAATGCACAAAAGTCAAATCAGAATGGAAAAGACTCAAAACCATCATCAACACCAAGATCAAAAGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGGAAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGACTGACCAAGAGGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAA
ORF Protein Sequence MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T45591-Ab Anti-NPM1 monoclonal antibody
    Target Antigen GM-Tg-g-T45591-Ag NPM1 protein
    ORF Viral Vector pGMLP000923 Human NPM1 Lentivirus plasmid
    ORF Viral Vector pGMLP005179 Human NPM1 Lentivirus plasmid
    ORF Viral Vector pGMAP000021 Human NPM1 Adenovirus plasmid
    ORF Viral Vector pGMAP000065 Human NPM1 Adenovirus plasmid
    ORF Viral Vector pGMAP000113 Human NPM1 Adenovirus plasmid
    ORF Viral Vector pGMAP000237 Human NPM1 Adenovirus plasmid
    ORF Viral Vector vGMLP000923 Human NPM1 Lentivirus particle
    ORF Viral Vector vGMLP005179 Human NPM1 Lentivirus particle
    ORF Viral Vector vGMAP000021 Human NPM1 Adenovirus particle
    ORF Viral Vector vGMAP000065 Human NPM1 Adenovirus particle
    ORF Viral Vector vGMAP000113 Human NPM1 Adenovirus particle
    ORF Viral Vector vGMAP000237 Human NPM1 Adenovirus particle


    Target information

    Target ID GM-T45591
    Target Name NPM1
    Gene ID 4869, 18148, 706883, 25498, 101094904, 479292, 614028, 100059112
    Gene Symbol and Synonyms B23,B23NP,NO38,NPM,NPM1
    Uniprot Accession P06748
    Uniprot Entry Name NPM_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000181163
    Target Classification Tumor-associated antigen (TAA)

    The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]



    About GMVC

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