Human PCBP2/hnRNP-E2/HNRNPE2 ORF/cDNA clone-Lentivirus particle (NM_021127)

Cat. No.: vGMLP001413

Pre-made Human PCBP2/hnRNP-E2/HNRNPE2 Lentiviral expression plasmid for PCBP2 lentivirus packaging, PCBP2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLP001413 Human PCBP2 Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLP001413
Gene Name PCBP2
Accession Number NM_021127
Gene ID 5094
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 1101 bp
Gene Alias hnRNP-E2,HNRNPE2,HNRPE2
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGCCTGGGAAGAAGGCGCGCAAGAACGCTCAACCGAGCCCCGCGCGGGCTCCAGCAGAGCTGGAAGTCGAGTGTGCTACTCAACTCAGGAGATTTGGAGACAAACTGAACTTCCGGCAGAAACTTCTGAATCTGATATCCAAACTCTTCTGCTCAGGAACCTGA
ORF Protein Sequence MPGKKARKNAQPSPARAPAELEVECATQLRRFGDKLNFRQKLLNLISKLFCSGT

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-IP1328-Ab Anti-PCBP2 monoclonal antibody
    Target Antigen GM-Tg-g-IP1328-Ag PCBP2 protein
    ORF Viral Vector pGMLP001413 Human PCBP2 Lentivirus plasmid
    ORF Viral Vector vGMLP001413 Human PCBP2 Lentivirus particle


    Target information

    Target ID GM-IP1328
    Target Name PCBP2
    Gene ID 5094, 18521, 703175, 363005, 101086733, 477596, 540653, 100062163
    Gene Symbol and Synonyms alphaCP-2,hnRNP-E2,HNRNPE2,HNRPE2,Hnrpx,PCBP2
    Uniprot Accession Q15366
    Uniprot Entry Name PCBP2_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Not Available
    Disease Not Available
    Gene Ensembl ENSG00000197111
    Target Classification Not Available

    The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]



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