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Anti-CLN8 monoclonal antibody
Pre-made anti-CLN8 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CLN8/CLN8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0563-Ab-1/ GM-Tg-hg-IP0563-Ab-2 | Anti-Human CLN8 monoclonal antibody | Human |
| GM-Tg-rg-IP0563-Ab-1/ GM-Tg-rg-IP0563-Ab-2 | Anti-Rat CLN8 monoclonal antibody | Rat |
| GM-Tg-mg-IP0563-Ab-1/ GM-Tg-mg-IP0563-Ab-2 | Anti-Mouse CLN8 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0563-Ab-1/ GM-Tg-cynog-IP0563-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLN8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0563-Ab-1/ GM-Tg-felg-IP0563-Ab-2 | Anti-Feline CLN8 monoclonal antibody | Feline |
| GM-Tg-cang-IP0563-Ab-1/ GM-Tg-cang-IP0563-Ab-2 | Anti-Canine CLN8 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0563-Ab-1/ GM-Tg-bovg-IP0563-Ab-2 | Anti-Bovine CLN8 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0563-Ab-1/ GM-Tg-equg-IP0563-Ab-2 | Anti-Equine CLN8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0563-Ab-1/ GM-Tg-hg-IP0563-Ab-2; GM-Tg-rg-IP0563-Ab-1/ GM-Tg-rg-IP0563-Ab-2; GM-Tg-mg-IP0563-Ab-1/ GM-Tg-mg-IP0563-Ab-2; GM-Tg-cynog-IP0563-Ab-1/ GM-Tg-cynog-IP0563-Ab-2; GM-Tg-felg-IP0563-Ab-1/ GM-Tg-felg-IP0563-Ab-2; GM-Tg-cang-IP0563-Ab-1/ GM-Tg-cang-IP0563-Ab-2; GM-Tg-bovg-IP0563-Ab-1/ GM-Tg-bovg-IP0563-Ab-2; GM-Tg-equg-IP0563-Ab-1/ GM-Tg-equg-IP0563-Ab-2 |
| Products Name | Anti-CLN8 monoclonal antibody |
| Format | mab |
| Target Name | CLN8 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CLN8 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0563-Ag-1 | Recombinant multi-species CLN8/ C8orf61/ EPMR protein |
| ORF Viral Vector | vGMLP000179 | human CLN8 Lentivirus particle |
| ORF Viral Vector | pGMLP000179 | human CLN8 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000355 | mouse Cln8 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000355 | mouse Cln8 Lentivirus particle |
Target information
| Target ID | GM-IP0563 |
| Target Name | CLN8 |
| Gene ID | 2055,26889,306619,716441,488558,101100714,530874,100065372 |
| Gene Symbol and Synonyms | C8orf61,CLN8,EPMR,mnd,TLCD6 |
| Uniprot Accession | Q9UBY8,Q6AYM9,Q5JZQ7 |
| Uniprot Entry Name | CLN8_HUMAN,CLN8_RAT,CLN8_CANLF |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000182372 |
| Target Classification | N/A |
The target: CLN8, gene name: CLN8, also named as C8orf61, EPMR. This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with a disorder characterized by progressive epilepsy with cognitive disabilities (EPMR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain. [provided by RefSeq, Jul 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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