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Anti-HTRA2 monoclonal antibody
Pre-made anti-HTRA2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HTRA2/HTRA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0992-Ab-1/ GM-Tg-hg-IP0992-Ab-2 | Anti-Human HTRA2 monoclonal antibody | Human |
| GM-Tg-rg-IP0992-Ab-1/ GM-Tg-rg-IP0992-Ab-2 | Anti-Rat HTRA2 monoclonal antibody | Rat |
| GM-Tg-mg-IP0992-Ab-1/ GM-Tg-mg-IP0992-Ab-2 | Anti-Mouse HTRA2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0992-Ab-1/ GM-Tg-cynog-IP0992-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HTRA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0992-Ab-1/ GM-Tg-felg-IP0992-Ab-2 | Anti-Feline HTRA2 monoclonal antibody | Feline |
| GM-Tg-cang-IP0992-Ab-1/ GM-Tg-cang-IP0992-Ab-2 | Anti-Canine HTRA2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0992-Ab-1/ GM-Tg-bovg-IP0992-Ab-2 | Anti-Bovine HTRA2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0992-Ab-1/ GM-Tg-equg-IP0992-Ab-2 | Anti-Equine HTRA2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0992-Ab-1/ GM-Tg-hg-IP0992-Ab-2; GM-Tg-rg-IP0992-Ab-1/ GM-Tg-rg-IP0992-Ab-2; GM-Tg-mg-IP0992-Ab-1/ GM-Tg-mg-IP0992-Ab-2; GM-Tg-cynog-IP0992-Ab-1/ GM-Tg-cynog-IP0992-Ab-2; GM-Tg-felg-IP0992-Ab-1/ GM-Tg-felg-IP0992-Ab-2; GM-Tg-cang-IP0992-Ab-1/ GM-Tg-cang-IP0992-Ab-2; GM-Tg-bovg-IP0992-Ab-1/ GM-Tg-bovg-IP0992-Ab-2; GM-Tg-equg-IP0992-Ab-1/ GM-Tg-equg-IP0992-Ab-2 |
| Products Name | Anti-HTRA2 monoclonal antibody |
| Format | mab |
| Target Name | HTRA2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HTRA2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0992-Ag-1 | Recombinant multi-species HTRA2/ MGCA8/ OMI protein |
| ORF Viral Vector | pGMLP003934 | human HTRA2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003934 | human HTRA2 Lentivirus particle |
| ORF Viral Vector | pGMLPm004870 | mouse Htra2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004870 | mouse Htra2 Lentivirus particle |
Target information
| Target ID | GM-IP0992 |
| Target Name | HTRA2 |
| Gene ID | 27429,64704,297376,709938,475782,768259,523039,100053688 |
| Gene Symbol and Synonyms | HTRA2,MGCA8,mnd2,OMI,PARK13,PRSS25 |
| Uniprot Accession | O43464,A0JNK3 |
| Uniprot Entry Name | HTRA2_HUMAN,HTRA2_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000115317 |
| Target Classification | N/A |
The target: HTRA2, gene name: HTRA2, also named as MGCA8, OMI, PARK13, PRSS25. This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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