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Anti-™EM158 monoclonal antibody
Pre-made anti-™EM158 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ™EM158/™EM158 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1998-Ab-1/ GM-Tg-hg-IP1998-Ab-2 | Anti-Human ™EM158 monoclonal antibody | Human |
| GM-Tg-rg-IP1998-Ab-1/ GM-Tg-rg-IP1998-Ab-2 | Anti-Rat ™EM158 monoclonal antibody | Rat |
| GM-Tg-mg-IP1998-Ab-1/ GM-Tg-mg-IP1998-Ab-2 | Anti-Mouse ™EM158 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1998-Ab-1/ GM-Tg-cynog-IP1998-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ™EM158 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1998-Ab-1/ GM-Tg-felg-IP1998-Ab-2 | Anti-Feline ™EM158 monoclonal antibody | Feline |
| GM-Tg-cang-IP1998-Ab-1/ GM-Tg-cang-IP1998-Ab-2 | Anti-Canine ™EM158 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1998-Ab-1/ GM-Tg-bovg-IP1998-Ab-2 | Anti-Bovine ™EM158 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1998-Ab-1/ GM-Tg-equg-IP1998-Ab-2 | Anti-Equine ™EM158 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1998-Ab-1/ GM-Tg-hg-IP1998-Ab-2; GM-Tg-rg-IP1998-Ab-1/ GM-Tg-rg-IP1998-Ab-2; GM-Tg-mg-IP1998-Ab-1/ GM-Tg-mg-IP1998-Ab-2; GM-Tg-cynog-IP1998-Ab-1/ GM-Tg-cynog-IP1998-Ab-2; GM-Tg-felg-IP1998-Ab-1/ GM-Tg-felg-IP1998-Ab-2; GM-Tg-cang-IP1998-Ab-1/ GM-Tg-cang-IP1998-Ab-2; GM-Tg-bovg-IP1998-Ab-1/ GM-Tg-bovg-IP1998-Ab-2; GM-Tg-equg-IP1998-Ab-1/ GM-Tg-equg-IP1998-Ab-2 |
| Products Name | Anti-™EM158 monoclonal antibody |
| Format | mab |
| Target Name | ™EM158 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-™EM158 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1998-Ag-1 | Recombinant multi-species ™158/ ™EM158/ BBP protein |
| ORF Viral Vector | pGMLP005144 | human ™EM158 Lentivirus plasmid |
| ORF Viral Vector | vGMLP005144 | human ™EM158 Lentivirus particle |
Target information
| Target ID | GM-IP1998 |
| Target Name | ™EM158 |
| Gene ID | 25907,72309,117582,106996039,119864589,111558414,788085,111768353 |
| Gene Symbol and Synonyms | 2310037P21Rik,BBP,p40BBP,RIS1,™EM158 |
| Uniprot Accession | Q8WZ71,Q91XV7,A2VDX9 |
| Uniprot Entry Name | ™158_HUMAN,™158_RAT,™158_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000249992 |
| Target Classification | N/A |
The target: ™EM158, gene name: ™EM158, also named as BBP, RIS1, p40BBP. Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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