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Anti-NKX2-8 monoclonal antibody
Pre-made anti-NKX2-8 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to NKX2-8/NKX2-8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2628-Ab-1/ GM-Tg-hg-IP2628-Ab-2 | Anti-Human NKX2-8 monoclonal antibody | Human |
| GM-Tg-rg-IP2628-Ab-1/ GM-Tg-rg-IP2628-Ab-2 | Anti-Rat NKX2-8 monoclonal antibody | Rat |
| GM-Tg-mg-IP2628-Ab-1/ GM-Tg-mg-IP2628-Ab-2 | Anti-Mouse NKX2-8 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2628-Ab-1/ GM-Tg-cynog-IP2628-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NKX2-8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2628-Ab-1/ GM-Tg-felg-IP2628-Ab-2 | Anti-Feline NKX2-8 monoclonal antibody | Feline |
| GM-Tg-cang-IP2628-Ab-1/ GM-Tg-cang-IP2628-Ab-2 | Anti-Canine NKX2-8 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2628-Ab-1/ GM-Tg-bovg-IP2628-Ab-2 | Anti-Bovine NKX2-8 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2628-Ab-1/ GM-Tg-equg-IP2628-Ab-2 | Anti-Equine NKX2-8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2628-Ab-1/ GM-Tg-hg-IP2628-Ab-2; GM-Tg-rg-IP2628-Ab-1/ GM-Tg-rg-IP2628-Ab-2; GM-Tg-mg-IP2628-Ab-1/ GM-Tg-mg-IP2628-Ab-2; GM-Tg-cynog-IP2628-Ab-1/ GM-Tg-cynog-IP2628-Ab-2; GM-Tg-felg-IP2628-Ab-1/ GM-Tg-felg-IP2628-Ab-2; GM-Tg-cang-IP2628-Ab-1/ GM-Tg-cang-IP2628-Ab-2; GM-Tg-bovg-IP2628-Ab-1/ GM-Tg-bovg-IP2628-Ab-2; GM-Tg-equg-IP2628-Ab-1/ GM-Tg-equg-IP2628-Ab-2 |
| Products Name | Anti-NKX2-8 monoclonal antibody |
| Format | mab |
| Target Name | NKX2-8 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-NKX2-8 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2628-Ag-1 | Recombinant multi-species NKX28/ NKX2-8/ NKX2.8 protein |
| ORF Viral Vector | vGMLP005135 | human Nkx2.8 Lentivirus particle |
| ORF Viral Vector | pGMLP005135 | human Nkx2.8 Lentivirus plasmid |
Target information
| Target ID | GM-IP2628 |
| Target Name | NKX2-8 |
| Gene ID | 26257,18094,299061,696564,609776,101085383,539075,106782219 |
| Gene Symbol and Synonyms | Nkx-2.9,NKX2-8,Nkx2-9,NKX2.8,Nkx2.9,NKX2H,tinman |
| Uniprot Accession | O15522 |
| Uniprot Entry Name | NKX28_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000136327 |
| Target Classification | N/A |
The target: NKX2-8, gene name: NKX2-8, also named as NKX2.8, NKX2H, Nkx2-9. The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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