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Anti-CLD19/ CLDN19/ HOMG5 monoclonal antibody
Anti-CLD19/ CLDN19/ HOMG5 antibody for FACS & in-vivo assay
Go to CLDN19/CLDN19 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0278-Ab-1/ GM-Tg-hg-MP0278-Ab-2 | Anti-Human CLDN19 monoclonal antibody | Human |
| GM-Tg-rg-MP0278-Ab-1/ GM-Tg-rg-MP0278-Ab-2 | Anti-Rat CLDN19 monoclonal antibody | Rat |
| GM-Tg-mg-MP0278-Ab-1/ GM-Tg-mg-MP0278-Ab-2 | Anti-Mouse CLDN19 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0278-Ab-1/ GM-Tg-cynog-MP0278-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLDN19 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0278-Ab-1/ GM-Tg-felg-MP0278-Ab-2 | Anti-Feline CLDN19 monoclonal antibody | Feline |
| GM-Tg-cang-MP0278-Ab-1/ GM-Tg-cang-MP0278-Ab-2 | Anti-Canine CLDN19 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0278-Ab-1/ GM-Tg-bovg-MP0278-Ab-2 | Anti-Bovine CLDN19 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0278-Ab-1/ GM-Tg-equg-MP0278-Ab-2 | Anti-Equine CLDN19 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0278-Ab-1/ GM-Tg-hg-MP0278-Ab-2; GM-Tg-rg-MP0278-Ab-1/ GM-Tg-rg-MP0278-Ab-2; GM-Tg-mg-MP0278-Ab-1/ GM-Tg-mg-MP0278-Ab-2; GM-Tg-cynog-MP0278-Ab-1/ GM-Tg-cynog-MP0278-Ab-2; GM-Tg-felg-MP0278-Ab-1/ GM-Tg-felg-MP0278-Ab-2; GM-Tg-cang-MP0278-Ab-1/ GM-Tg-cang-MP0278-Ab-2; GM-Tg-bovg-MP0278-Ab-1/ GM-Tg-bovg-MP0278-Ab-2; GM-Tg-equg-MP0278-Ab-1/ GM-Tg-equg-MP0278-Ab-2 |
| Products Name | Anti-CLDN19 monoclonal antibody |
| Format | mab |
| Target Name | CLDN19 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLDN19 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CLD19/ CLDN19/ HOMG5 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP004709 | human CLDN19 Lentivirus particle |
| ORF Viral Vector | pGMLP004709 | human CLDN19 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004684 | mouse Cldn19 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004684 | mouse Cldn19 Lentivirus particle |
Target information
| Target ID | GM-MP0278 |
| Target Name | CLDN19 |
| Gene ID | 149461,242653,298487,697807,607005,101093875,513034,100053591 |
| Gene Symbol and Synonyms | claudin-19,CLDN19,HOMG5 |
| Uniprot Accession | Q8N6F1,Q5QT56 |
| Uniprot Entry Name | CLD19_HUMAN,CLD19_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000164007 |
| Target Classification | N/A |
The target: CLDN19, gene name: CLDN19, also named as HOMG5. The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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