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Anti-CRUM3/ CRB3 monoclonal antibody
Anti-CRUM3/ CRB3 antibody for FACS & in-vivo assay
Go to CRB3/CRB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0333-Ab-1/ GM-Tg-hg-MP0333-Ab-2 | Anti-Human CRB3 monoclonal antibody | Human |
| GM-Tg-rg-MP0333-Ab-1/ GM-Tg-rg-MP0333-Ab-2 | Anti-Rat CRB3 monoclonal antibody | Rat |
| GM-Tg-mg-MP0333-Ab-1/ GM-Tg-mg-MP0333-Ab-2 | Anti-Mouse CRB3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0333-Ab-1/ GM-Tg-cynog-MP0333-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CRB3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0333-Ab-1/ GM-Tg-felg-MP0333-Ab-2 | Anti-Feline CRB3 monoclonal antibody | Feline |
| GM-Tg-cang-MP0333-Ab-1/ GM-Tg-cang-MP0333-Ab-2 | Anti-Canine CRB3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0333-Ab-1/ GM-Tg-bovg-MP0333-Ab-2 | Anti-Bovine CRB3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0333-Ab-1/ GM-Tg-equg-MP0333-Ab-2 | Anti-Equine CRB3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0333-Ab-1/ GM-Tg-hg-MP0333-Ab-2; GM-Tg-rg-MP0333-Ab-1/ GM-Tg-rg-MP0333-Ab-2; GM-Tg-mg-MP0333-Ab-1/ GM-Tg-mg-MP0333-Ab-2; GM-Tg-cynog-MP0333-Ab-1/ GM-Tg-cynog-MP0333-Ab-2; GM-Tg-felg-MP0333-Ab-1/ GM-Tg-felg-MP0333-Ab-2; GM-Tg-cang-MP0333-Ab-1/ GM-Tg-cang-MP0333-Ab-2; GM-Tg-bovg-MP0333-Ab-1/ GM-Tg-bovg-MP0333-Ab-2; GM-Tg-equg-MP0333-Ab-1/ GM-Tg-equg-MP0333-Ab-2 |
| Products Name | Anti-CRB3 monoclonal antibody |
| Format | mab |
| Target Name | CRB3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CRB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CRUM3/ CRB3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAAV000094 | human CRB3 AAV particle |
| ORF Viral Vector | pGMAAV000094 | human CRB3 AAV plasmid |
| ORF Viral Vector | pGMLPm004535 | mouse Crb3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004535 | mouse Crb3 Lentivirus particle |
Target information
| Target ID | GM-MP0333 |
| Target Name | CRB3 |
| Gene ID | 92359,224912,301112,700086,100855851,109493927,787466,100065707 |
| Gene Symbol and Synonyms | 5730439B18,CRB3 |
| Uniprot Accession | Q9BUF7,A0A5F4BST2 |
| Uniprot Entry Name | CRUM3_HUMAN,CRUM3_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000130545 |
| Target Classification | N/A |
The target: CRB3, gene name: CRB3, also named as . This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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