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Anti-CY24A/ CYBA/ p22-PHOX monoclonal antibody
Anti-CY24A/ CYBA/ p22-PHOX antibody for FACS & in-vivo assay
Go to CYBA/CYBA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0344-Ab-1/ GM-Tg-hg-MP0344-Ab-2 | Anti-Human CYBA monoclonal antibody | Human |
| GM-Tg-rg-MP0344-Ab-1/ GM-Tg-rg-MP0344-Ab-2 | Anti-Rat CYBA monoclonal antibody | Rat |
| GM-Tg-mg-MP0344-Ab-1/ GM-Tg-mg-MP0344-Ab-2 | Anti-Mouse CYBA monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0344-Ab-1/ GM-Tg-cynog-MP0344-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYBA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0344-Ab-1/ GM-Tg-felg-MP0344-Ab-2 | Anti-Feline CYBA monoclonal antibody | Feline |
| GM-Tg-cang-MP0344-Ab-1/ GM-Tg-cang-MP0344-Ab-2 | Anti-Canine CYBA monoclonal antibody | Canine |
| GM-Tg-bovg-MP0344-Ab-1/ GM-Tg-bovg-MP0344-Ab-2 | Anti-Bovine CYBA monoclonal antibody | Bovine |
| GM-Tg-equg-MP0344-Ab-1/ GM-Tg-equg-MP0344-Ab-2 | Anti-Equine CYBA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0344-Ab-1/ GM-Tg-hg-MP0344-Ab-2; GM-Tg-rg-MP0344-Ab-1/ GM-Tg-rg-MP0344-Ab-2; GM-Tg-mg-MP0344-Ab-1/ GM-Tg-mg-MP0344-Ab-2; GM-Tg-cynog-MP0344-Ab-1/ GM-Tg-cynog-MP0344-Ab-2; GM-Tg-felg-MP0344-Ab-1/ GM-Tg-felg-MP0344-Ab-2; GM-Tg-cang-MP0344-Ab-1/ GM-Tg-cang-MP0344-Ab-2; GM-Tg-bovg-MP0344-Ab-1/ GM-Tg-bovg-MP0344-Ab-2; GM-Tg-equg-MP0344-Ab-1/ GM-Tg-equg-MP0344-Ab-2 |
| Products Name | Anti-CYBA monoclonal antibody |
| Format | mab |
| Target Name | CYBA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CYBA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CY24A/ CYBA/ p22-PHOX VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP004603 | human CYBA Lentivirus particle |
| ORF Viral Vector | pGMLP004603 | human CYBA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001892 | mouse Cyba Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001892 | mouse Cyba Lentivirus particle |
Target information
| Target ID | GM-MP0344 |
| Target Name | CYBA |
| Gene ID | 1535,13057,79129,696748,489664,101091745,281111,100049843 |
| Gene Symbol and Synonyms | b558,CGD4,CYBA,nmf333,p22-PHOX,p22phox,Phox |
| Uniprot Accession | P13498,Q62737,O46521 |
| Uniprot Entry Name | CY24A_HUMAN,CY24A_RAT,CY24A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000051523 |
| Target Classification | N/A |
The target: CYBA, gene name: CYBA, also named as p22-PHOX. Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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