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Anti-EDAR/ DL/ ECTD10A monoclonal antibody
Anti-EDAR/ DL/ ECTD10A antibody for FACS & in-vivo assay
Go to EDAR/EDAR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0391-Ab-1/ GM-Tg-hg-MP0391-Ab-2 | Anti-Human EDAR monoclonal antibody | Human |
| GM-Tg-rg-MP0391-Ab-1/ GM-Tg-rg-MP0391-Ab-2 | Anti-Rat EDAR monoclonal antibody | Rat |
| GM-Tg-mg-MP0391-Ab-1/ GM-Tg-mg-MP0391-Ab-2 | Anti-Mouse EDAR monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0391-Ab-1/ GM-Tg-cynog-MP0391-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EDAR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0391-Ab-1/ GM-Tg-felg-MP0391-Ab-2 | Anti-Feline EDAR monoclonal antibody | Feline |
| GM-Tg-cang-MP0391-Ab-1/ GM-Tg-cang-MP0391-Ab-2 | Anti-Canine EDAR monoclonal antibody | Canine |
| GM-Tg-bovg-MP0391-Ab-1/ GM-Tg-bovg-MP0391-Ab-2 | Anti-Bovine EDAR monoclonal antibody | Bovine |
| GM-Tg-equg-MP0391-Ab-1/ GM-Tg-equg-MP0391-Ab-2 | Anti-Equine EDAR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0391-Ab-1/ GM-Tg-hg-MP0391-Ab-2; GM-Tg-rg-MP0391-Ab-1/ GM-Tg-rg-MP0391-Ab-2; GM-Tg-mg-MP0391-Ab-1/ GM-Tg-mg-MP0391-Ab-2; GM-Tg-cynog-MP0391-Ab-1/ GM-Tg-cynog-MP0391-Ab-2; GM-Tg-felg-MP0391-Ab-1/ GM-Tg-felg-MP0391-Ab-2; GM-Tg-cang-MP0391-Ab-1/ GM-Tg-cang-MP0391-Ab-2; GM-Tg-bovg-MP0391-Ab-1/ GM-Tg-bovg-MP0391-Ab-2; GM-Tg-equg-MP0391-Ab-1/ GM-Tg-equg-MP0391-Ab-2 |
| Products Name | Anti-EDAR monoclonal antibody |
| Format | mab |
| Target Name | EDAR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EDAR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EDAR/ DL/ ECTD10A VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001634 | human EDAR Lentivirus plasmid |
| ORF Viral Vector | vGMLP001634 | human EDAR Lentivirus particle |
Target information
| Target ID | GM-MP0391 |
| Target Name | EDAR |
| Gene ID | 10913,13608,365581,695059,481305,101096644,613947,100060614 |
| Gene Symbol and Synonyms | DL,ECTD10A,ECTD10B,ED1R,ED3,ED5,EDA-A1R,EDA1R,EDA3,EDAR,HRM1,RGD1561714 |
| Uniprot Accession | Q9UNE0 |
| Uniprot Entry Name | EDAR_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000135960 |
| Target Classification | N/A |
The target: EDAR, gene name: EDAR, also named as DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, HRM1. This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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