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Anti-EMP2/ XMP monoclonal antibody
Anti-EMP2/ XMP antibody for FACS & in-vivo assay
Go to EMP2/EMP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0404-Ab-1/ GM-Tg-hg-MP0404-Ab-2 | Anti-Human EMP2 monoclonal antibody | Human |
| GM-Tg-rg-MP0404-Ab-1/ GM-Tg-rg-MP0404-Ab-2 | Anti-Rat EMP2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0404-Ab-1/ GM-Tg-mg-MP0404-Ab-2 | Anti-Mouse EMP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0404-Ab-1/ GM-Tg-cynog-MP0404-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EMP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0404-Ab-1/ GM-Tg-felg-MP0404-Ab-2 | Anti-Feline EMP2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0404-Ab-1/ GM-Tg-cang-MP0404-Ab-2 | Anti-Canine EMP2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0404-Ab-1/ GM-Tg-bovg-MP0404-Ab-2 | Anti-Bovine EMP2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0404-Ab-1/ GM-Tg-equg-MP0404-Ab-2 | Anti-Equine EMP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0404-Ab-1/ GM-Tg-hg-MP0404-Ab-2; GM-Tg-rg-MP0404-Ab-1/ GM-Tg-rg-MP0404-Ab-2; GM-Tg-mg-MP0404-Ab-1/ GM-Tg-mg-MP0404-Ab-2; GM-Tg-cynog-MP0404-Ab-1/ GM-Tg-cynog-MP0404-Ab-2; GM-Tg-felg-MP0404-Ab-1/ GM-Tg-felg-MP0404-Ab-2; GM-Tg-cang-MP0404-Ab-1/ GM-Tg-cang-MP0404-Ab-2; GM-Tg-bovg-MP0404-Ab-1/ GM-Tg-bovg-MP0404-Ab-2; GM-Tg-equg-MP0404-Ab-1/ GM-Tg-equg-MP0404-Ab-2 |
| Products Name | Anti-EMP2 monoclonal antibody |
| Format | mab |
| Target Name | EMP2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EMP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EMP2/ XMP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000850 | human EMP2 Lentivirus particle |
| ORF Viral Vector | pGMLP000850 | human EMP2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000249 | mouse Emp2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000249 | mouse Emp2 Lentivirus particle |
Target information
| Target ID | GM-MP0404 |
| Target Name | EMP2 |
| Gene ID | 2013,13731,360468,710315,490010,101085593,507667,100051255 |
| Gene Symbol and Synonyms | EMP-2,EMP2,XMP |
| Uniprot Accession | P54851,Q66HH2,Q2NKU9 |
| Uniprot Entry Name | EMP2_HUMAN,EMP2_RAT,EMP2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000213853 |
| Target Classification | N/A |
The target: EMP2, gene name: EMP2, also named as XMP. This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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