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Anti-GFRA1/ GDNFR/ GDNFRA monoclonal antibody
Anti-GFRA1/ GDNFR/ GDNFRA antibody for FACS & in-vivo assay
Go to GFRA1/GFRA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0478-Ab-1/ GM-Tg-hg-MP0478-Ab-2 | Anti-Human GFRA1 monoclonal antibody | Human |
| GM-Tg-rg-MP0478-Ab-1/ GM-Tg-rg-MP0478-Ab-2 | Anti-Rat GFRA1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0478-Ab-1/ GM-Tg-mg-MP0478-Ab-2 | Anti-Mouse GFRA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0478-Ab-1/ GM-Tg-cynog-MP0478-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GFRA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0478-Ab-1/ GM-Tg-felg-MP0478-Ab-2 | Anti-Feline GFRA1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0478-Ab-1/ GM-Tg-cang-MP0478-Ab-2 | Anti-Canine GFRA1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0478-Ab-1/ GM-Tg-bovg-MP0478-Ab-2 | Anti-Bovine GFRA1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0478-Ab-1/ GM-Tg-equg-MP0478-Ab-2 | Anti-Equine GFRA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0478-Ab-1/ GM-Tg-hg-MP0478-Ab-2; GM-Tg-rg-MP0478-Ab-1/ GM-Tg-rg-MP0478-Ab-2; GM-Tg-mg-MP0478-Ab-1/ GM-Tg-mg-MP0478-Ab-2; GM-Tg-cynog-MP0478-Ab-1/ GM-Tg-cynog-MP0478-Ab-2; GM-Tg-felg-MP0478-Ab-1/ GM-Tg-felg-MP0478-Ab-2; GM-Tg-cang-MP0478-Ab-1/ GM-Tg-cang-MP0478-Ab-2; GM-Tg-bovg-MP0478-Ab-1/ GM-Tg-bovg-MP0478-Ab-2; GM-Tg-equg-MP0478-Ab-1/ GM-Tg-equg-MP0478-Ab-2 |
| Products Name | Anti-GFRA1 monoclonal antibody |
| Format | mab |
| Target Name | GFRA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GFRA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GFRA1/ GDNFR/ GDNFRA VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0478-Ag-1 | GDNF family receptor alpha 1 (GFRA1) protein |
| ORF Viral Vector | pGMLP001513 | human GFRA1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001513 | human GFRA1 Lentivirus particle |
| ORF Viral Vector | pGMLPm001786 | mouse Gfra1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001786 | mouse Gfra1 Lentivirus particle |
Target information
| Target ID | GM-MP0478 |
| Target Name | GFRA1 |
| Gene ID | 2674,14585,25454,706353,609114,101085242,534801,100067810 |
| Gene Symbol and Synonyms | GDNFR,GDNFR-alpha-1,GDNFRA,GFR-ALPHA-1,GFRA1,GFRalpha-1,RET1L,RETL1,RHDA4,TRNR1 |
| Uniprot Accession | P56159,Q62997 |
| Uniprot Entry Name | GFRA1_HUMAN,GFRA1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000151892 |
| Target Classification | N/A |
The target: GFRA1, gene name: GFRA1, also named as GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1. This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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