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Anti-GPV/ GP5/ CD42d monoclonal antibody
Anti-GPV/ GP5/ CD42d antibody for FACS & in-vivo assay
Go to GP5/GP5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0488-Ab-1/ GM-Tg-hg-MP0488-Ab-2 | Anti-Human GP5 monoclonal antibody | Human |
| GM-Tg-rg-MP0488-Ab-1/ GM-Tg-rg-MP0488-Ab-2 | Anti-Rat GP5 monoclonal antibody | Rat |
| GM-Tg-mg-MP0488-Ab-1/ GM-Tg-mg-MP0488-Ab-2 | Anti-Mouse GP5 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0488-Ab-1/ GM-Tg-cynog-MP0488-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GP5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0488-Ab-1/ GM-Tg-felg-MP0488-Ab-2 | Anti-Feline GP5 monoclonal antibody | Feline |
| GM-Tg-cang-MP0488-Ab-1/ GM-Tg-cang-MP0488-Ab-2 | Anti-Canine GP5 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0488-Ab-1/ GM-Tg-bovg-MP0488-Ab-2 | Anti-Bovine GP5 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0488-Ab-1/ GM-Tg-equg-MP0488-Ab-2 | Anti-Equine GP5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0488-Ab-1/ GM-Tg-hg-MP0488-Ab-2; GM-Tg-rg-MP0488-Ab-1/ GM-Tg-rg-MP0488-Ab-2; GM-Tg-mg-MP0488-Ab-1/ GM-Tg-mg-MP0488-Ab-2; GM-Tg-cynog-MP0488-Ab-1/ GM-Tg-cynog-MP0488-Ab-2; GM-Tg-felg-MP0488-Ab-1/ GM-Tg-felg-MP0488-Ab-2; GM-Tg-cang-MP0488-Ab-1/ GM-Tg-cang-MP0488-Ab-2; GM-Tg-bovg-MP0488-Ab-1/ GM-Tg-bovg-MP0488-Ab-2; GM-Tg-equg-MP0488-Ab-1/ GM-Tg-equg-MP0488-Ab-2 |
| Products Name | Anti-GP5 monoclonal antibody |
| Format | mab |
| Target Name | GP5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GP5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GPV/ GP5/ CD42d VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001777 | human GP5 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001777 | human GP5 Lentivirus particle |
| ORF Viral Vector | pGMLPm003943 | mouse Gp5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003943 | mouse Gp5 Lentivirus particle |
Target information
| Target ID | GM-MP0488 |
| Target Name | GP5 |
| Gene ID | 2814,14729,25259,707776,101090457,522692,100060025 |
| Gene Symbol and Synonyms | CD42d,GP5,GPV,PLGPV |
| Uniprot Accession | P40197,O08770 |
| Uniprot Entry Name | GPV_HUMAN,GPV_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000178732 |
| Target Classification | N/A |
The target: GP5, gene name: GP5, also named as CD42d, GPV. Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
