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Anti-GP143/ GPR143/ NYS6 monoclonal antibody
Anti-GP143/ GPR143/ NYS6 antibody for FACS & in-vivo assay
Go to GPR143/GPR143 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0510-Ab-1/ GM-Tg-hg-MP0510-Ab-2 | Anti-Human GPR143 monoclonal antibody | Human |
| GM-Tg-rg-MP0510-Ab-1/ GM-Tg-rg-MP0510-Ab-2 | Anti-Rat GPR143 monoclonal antibody | Rat |
| GM-Tg-mg-MP0510-Ab-1/ GM-Tg-mg-MP0510-Ab-2 | Anti-Mouse GPR143 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0510-Ab-1/ GM-Tg-cynog-MP0510-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GPR143 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0510-Ab-1/ GM-Tg-felg-MP0510-Ab-2 | Anti-Feline GPR143 monoclonal antibody | Feline |
| GM-Tg-cang-MP0510-Ab-1/ GM-Tg-cang-MP0510-Ab-2 | Anti-Canine GPR143 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0510-Ab-1/ GM-Tg-bovg-MP0510-Ab-2 | Anti-Bovine GPR143 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0510-Ab-1/ GM-Tg-equg-MP0510-Ab-2 | Anti-Equine GPR143 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0510-Ab-1/ GM-Tg-hg-MP0510-Ab-2; GM-Tg-rg-MP0510-Ab-1/ GM-Tg-rg-MP0510-Ab-2; GM-Tg-mg-MP0510-Ab-1/ GM-Tg-mg-MP0510-Ab-2; GM-Tg-cynog-MP0510-Ab-1/ GM-Tg-cynog-MP0510-Ab-2; GM-Tg-felg-MP0510-Ab-1/ GM-Tg-felg-MP0510-Ab-2; GM-Tg-cang-MP0510-Ab-1/ GM-Tg-cang-MP0510-Ab-2; GM-Tg-bovg-MP0510-Ab-1/ GM-Tg-bovg-MP0510-Ab-2; GM-Tg-equg-MP0510-Ab-1/ GM-Tg-equg-MP0510-Ab-2 |
| Products Name | Anti-GPR143 monoclonal antibody |
| Format | mab |
| Target Name | GPR143 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GPR143 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GP143/ GPR143/ NYS6 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001778 | human GPR143 Lentivirus particle |
| ORF Viral Vector | pGMLP001778 | human GPR143 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005371 | mouse Gpr143 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005371 | mouse Gpr143 Lentivirus particle |
Target information
| Target ID | GM-MP0510 |
| Target Name | GPR143 |
| Gene ID | 4935,18241,302619,709148,491733,101087044,613505,100147328 |
| Gene Symbol and Synonyms | GPR143,NYS6,OA1,RGD1565799 |
| Uniprot Accession | P51810 |
| Uniprot Entry Name | GP143_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000101850 |
| Target Classification | GPCR |
The target: GPR143, gene name: GPR143, also named as NYS6, OA1. This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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