Anti-HAVR1/ HAVCR1/ CD365 monoclonal antibody

Anti-HAVR1/ HAVCR1/ CD365 antibody for FACS & in-vivo assay

Target products collectionGo to HAVCR1/HAVCR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0572-Ab-1/ GM-Tg-hg-MP0572-Ab-2Anti-Human HAVCR1 monoclonal antibodyHuman
GM-Tg-rg-MP0572-Ab-1/ GM-Tg-rg-MP0572-Ab-2Anti-Rat HAVCR1 monoclonal antibodyRat
GM-Tg-mg-MP0572-Ab-1/ GM-Tg-mg-MP0572-Ab-2Anti-Mouse HAVCR1 monoclonal antibodyMouse
GM-Tg-cynog-MP0572-Ab-1/ GM-Tg-cynog-MP0572-Ab-2Anti-Cynomolgus/ Rhesus macaque HAVCR1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0572-Ab-1/ GM-Tg-felg-MP0572-Ab-2Anti-Feline HAVCR1 monoclonal antibodyFeline
GM-Tg-cang-MP0572-Ab-1/ GM-Tg-cang-MP0572-Ab-2Anti-Canine HAVCR1 monoclonal antibodyCanine
GM-Tg-bovg-MP0572-Ab-1/ GM-Tg-bovg-MP0572-Ab-2Anti-Bovine HAVCR1 monoclonal antibodyBovine
GM-Tg-equg-MP0572-Ab-1/ GM-Tg-equg-MP0572-Ab-2Anti-Equine HAVCR1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0572-Ab-1/ GM-Tg-hg-MP0572-Ab-2; GM-Tg-rg-MP0572-Ab-1/ GM-Tg-rg-MP0572-Ab-2;
GM-Tg-mg-MP0572-Ab-1/ GM-Tg-mg-MP0572-Ab-2; GM-Tg-cynog-MP0572-Ab-1/ GM-Tg-cynog-MP0572-Ab-2;
GM-Tg-felg-MP0572-Ab-1/ GM-Tg-felg-MP0572-Ab-2; GM-Tg-cang-MP0572-Ab-1/ GM-Tg-cang-MP0572-Ab-2;
GM-Tg-bovg-MP0572-Ab-1/ GM-Tg-bovg-MP0572-Ab-2; GM-Tg-equg-MP0572-Ab-1/ GM-Tg-equg-MP0572-Ab-2
Products NameAnti-HAVCR1 monoclonal antibody
Formatmab
Target NameHAVCR1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HAVCR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species HAVR1/ HAVCR1/ CD365 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP001952human HAVCR1 Lentivirus particle
    ORF Viral VectorpGMLP001952human HAVCR1 Lentivirus plasmid
    ORF Viral VectorpGMLPm003696mouse Havcr1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003696mouse Havcr1 Lentivirus particle


    Target information

    Target IDGM-MP0572
    Target NameHAVCR1
    Gene ID26762,715333,612069,101099778
    Gene Symbol and SynonymsCD365,HAVCR,HAVCR-1,HAVCR1,KIM-1,KIM1,TIM,TIM-1,TIM1,TIMD-1,TIMD1
    Uniprot AccessionQ96D42
    Uniprot Entry NameHAVR1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseRenal fibrosis, Sickle Cell Nephropathy, Type 1 diabetes mellitus with diabetic nephropathy, Type 2 diabetes mellitus, Vasculitis, Vesicoureteral reflux, Acute kidney failure, Autosomal Dominant Polycystic Kidney Disease, Complications of kidney transplant, Congenital hydronephrosis, Cystic fibrosis with pulmonary manifestations, Injury to Kidney, Intraoperative Renal Injury, Kidney disease, Neonatal urinary tract infection, Nephropathy induced by heavy metals, Proteinuria, Renal cell carcinoma, Hydronephrosis, Coronary artery disease, Nephrotic syndrome with diffuse membranous glomerulonephritis
    Gene EnsemblENSG00000113249
    Target ClassificationN/A

    The target: HAVCR1, gene name: HAVCR1, also named as CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1. The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses. [provided by RefSeq, Sep 2021].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.