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Anti-HCST/ DAP10/ KAP10 monoclonal antibody
Anti-HCST/ DAP10/ KAP10 antibody for FACS & in-vivo assay
Go to HCST/HCST products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0574-Ab-1/ GM-Tg-hg-MP0574-Ab-2 | Anti-Human HCST monoclonal antibody | Human |
| GM-Tg-rg-MP0574-Ab-1/ GM-Tg-rg-MP0574-Ab-2 | Anti-Rat HCST monoclonal antibody | Rat |
| GM-Tg-mg-MP0574-Ab-1/ GM-Tg-mg-MP0574-Ab-2 | Anti-Mouse HCST monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0574-Ab-1/ GM-Tg-cynog-MP0574-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HCST monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0574-Ab-1/ GM-Tg-felg-MP0574-Ab-2 | Anti-Feline HCST monoclonal antibody | Feline |
| GM-Tg-cang-MP0574-Ab-1/ GM-Tg-cang-MP0574-Ab-2 | Anti-Canine HCST monoclonal antibody | Canine |
| GM-Tg-bovg-MP0574-Ab-1/ GM-Tg-bovg-MP0574-Ab-2 | Anti-Bovine HCST monoclonal antibody | Bovine |
| GM-Tg-equg-MP0574-Ab-1/ GM-Tg-equg-MP0574-Ab-2 | Anti-Equine HCST monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0574-Ab-1/ GM-Tg-hg-MP0574-Ab-2; GM-Tg-rg-MP0574-Ab-1/ GM-Tg-rg-MP0574-Ab-2; GM-Tg-mg-MP0574-Ab-1/ GM-Tg-mg-MP0574-Ab-2; GM-Tg-cynog-MP0574-Ab-1/ GM-Tg-cynog-MP0574-Ab-2; GM-Tg-felg-MP0574-Ab-1/ GM-Tg-felg-MP0574-Ab-2; GM-Tg-cang-MP0574-Ab-1/ GM-Tg-cang-MP0574-Ab-2; GM-Tg-bovg-MP0574-Ab-1/ GM-Tg-bovg-MP0574-Ab-2; GM-Tg-equg-MP0574-Ab-1/ GM-Tg-equg-MP0574-Ab-2 |
| Products Name | Anti-HCST monoclonal antibody |
| Format | mab |
| Target Name | HCST |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HCST benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HCST/ DAP10/ KAP10 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000743 | human HCST Lentivirus particle |
| ORF Viral Vector | pGMLP000743 | human HCST Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000098 | mouse Hcst Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000098 | mouse Hcst Lentivirus particle |
Target information
| Target ID | GM-MP0574 |
| Target Name | HCST |
| Gene ID | 10870,23900,474146,574152,612627,101097286,767892,100060115 |
| Gene Symbol and Synonyms | DAP10,HCST,KAP10,PIK3AP |
| Uniprot Accession | Q9UBK5,Q6X9T8,Q8WNQ9,Q1XF11 |
| Uniprot Entry Name | HCST_HUMAN,HCST_MACMU,HCST_RAT,HCST_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000126264 |
| Target Classification | N/A |
The target: HCST, gene name: HCST, also named as DAP10, KAP10, PIK3AP. This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
