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Anti-IHH/ BDA1/ HHG2 monoclonal antibody
Anti-IHH/ BDA1/ HHG2 antibody for FACS & in-vivo assay
Go to IHH/IHH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0618-Ab-1/ GM-Tg-hg-MP0618-Ab-2 | Anti-Human IHH monoclonal antibody | Human |
| GM-Tg-rg-MP0618-Ab-1/ GM-Tg-rg-MP0618-Ab-2 | Anti-Rat IHH monoclonal antibody | Rat |
| GM-Tg-mg-MP0618-Ab-1/ GM-Tg-mg-MP0618-Ab-2 | Anti-Mouse IHH monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0618-Ab-1/ GM-Tg-cynog-MP0618-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IHH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0618-Ab-1/ GM-Tg-felg-MP0618-Ab-2 | Anti-Feline IHH monoclonal antibody | Feline |
| GM-Tg-cang-MP0618-Ab-1/ GM-Tg-cang-MP0618-Ab-2 | Anti-Canine IHH monoclonal antibody | Canine |
| GM-Tg-bovg-MP0618-Ab-1/ GM-Tg-bovg-MP0618-Ab-2 | Anti-Bovine IHH monoclonal antibody | Bovine |
| GM-Tg-equg-MP0618-Ab-1/ GM-Tg-equg-MP0618-Ab-2 | Anti-Equine IHH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0618-Ab-1/ GM-Tg-hg-MP0618-Ab-2; GM-Tg-rg-MP0618-Ab-1/ GM-Tg-rg-MP0618-Ab-2; GM-Tg-mg-MP0618-Ab-1/ GM-Tg-mg-MP0618-Ab-2; GM-Tg-cynog-MP0618-Ab-1/ GM-Tg-cynog-MP0618-Ab-2; GM-Tg-felg-MP0618-Ab-1/ GM-Tg-felg-MP0618-Ab-2; GM-Tg-cang-MP0618-Ab-1/ GM-Tg-cang-MP0618-Ab-2; GM-Tg-bovg-MP0618-Ab-1/ GM-Tg-bovg-MP0618-Ab-2; GM-Tg-equg-MP0618-Ab-1/ GM-Tg-equg-MP0618-Ab-2 |
| Products Name | Anti-IHH monoclonal antibody |
| Format | mab |
| Target Name | IHH |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IHH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species IHH/ BDA1/ HHG2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003659 | human IHH Lentivirus plasmid |
| ORF Viral Vector | vGMLP003659 | human IHH Lentivirus particle |
Target information
| Target ID | GM-MP0618 |
| Target Name | IHH |
| Gene ID | 3549,16147,84399,704046,488533,101100146,522714,100033984 |
| Gene Symbol and Synonyms | BDA1,HHG-2,HHG2,IHH |
| Uniprot Accession | Q14623 |
| Uniprot Entry Name | IHH_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000163501 |
| Target Classification | N/A |
The target: IHH, gene name: IHH, also named as BDA1, HHG2. This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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