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Anti-KCNE2/ ATFB4/ LQT5 monoclonal antibody
Anti-KCNE2/ ATFB4/ LQT5 antibody for FACS & in-vivo assay
Go to KCNE2/KCNE2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0656-Ab-1/ GM-Tg-hg-MP0656-Ab-2 | Anti-Human KCNE2 monoclonal antibody | Human |
| GM-Tg-rg-MP0656-Ab-1/ GM-Tg-rg-MP0656-Ab-2 | Anti-Rat KCNE2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0656-Ab-1/ GM-Tg-mg-MP0656-Ab-2 | Anti-Mouse KCNE2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0656-Ab-1/ GM-Tg-cynog-MP0656-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNE2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0656-Ab-1/ GM-Tg-felg-MP0656-Ab-2 | Anti-Feline KCNE2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0656-Ab-1/ GM-Tg-cang-MP0656-Ab-2 | Anti-Canine KCNE2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0656-Ab-1/ GM-Tg-bovg-MP0656-Ab-2 | Anti-Bovine KCNE2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0656-Ab-1/ GM-Tg-equg-MP0656-Ab-2 | Anti-Equine KCNE2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0656-Ab-1/ GM-Tg-hg-MP0656-Ab-2; GM-Tg-rg-MP0656-Ab-1/ GM-Tg-rg-MP0656-Ab-2; GM-Tg-mg-MP0656-Ab-1/ GM-Tg-mg-MP0656-Ab-2; GM-Tg-cynog-MP0656-Ab-1/ GM-Tg-cynog-MP0656-Ab-2; GM-Tg-felg-MP0656-Ab-1/ GM-Tg-felg-MP0656-Ab-2; GM-Tg-cang-MP0656-Ab-1/ GM-Tg-cang-MP0656-Ab-2; GM-Tg-bovg-MP0656-Ab-1/ GM-Tg-bovg-MP0656-Ab-2; GM-Tg-equg-MP0656-Ab-1/ GM-Tg-equg-MP0656-Ab-2 |
| Products Name | Anti-KCNE2 monoclonal antibody |
| Format | mab |
| Target Name | KCNE2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCNE2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCNE2/ ATFB4/ LQT5 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000905 | human KCNE2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000905 | human KCNE2 Lentivirus particle |
| ORF Viral Vector | pGMLPm000999 | mouse Kcne2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000999 | mouse Kcne2 Lentivirus particle |
Target information
| Target ID | GM-MP0656 |
| Target Name | KCNE2 |
| Gene ID | 9992,246133,171138,403471,101086335,768025,100062720 |
| Gene Symbol and Synonyms | 2200002I16Rik,ATFB4,KCNE2,LQT5,LQT6,MIRP1 |
| Uniprot Accession | Q9Y6J6,P63161 |
| Uniprot Entry Name | KCNE2_HUMAN,KCNE2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000159197 |
| Target Classification | N/A |
The target: KCNE2, gene name: KCNE2, also named as ATFB4, LQT5, LQT6, MIRP1. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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