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Anti-EPCR/ PROCR/ CCCA monoclonal antibody
Anti-EPCR/ PROCR/ CCCA antibody for FACS & in-vivo assay
Go to PROCR/PROCR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1406-Ab-1/ GM-Tg-hg-MP1406-Ab-2 | Anti-Human PROCR monoclonal antibody | Human |
| GM-Tg-rg-MP1406-Ab-1/ GM-Tg-rg-MP1406-Ab-2 | Anti-Rat PROCR monoclonal antibody | Rat |
| GM-Tg-mg-MP1406-Ab-1/ GM-Tg-mg-MP1406-Ab-2 | Anti-Mouse PROCR monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1406-Ab-1/ GM-Tg-cynog-MP1406-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PROCR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1406-Ab-1/ GM-Tg-felg-MP1406-Ab-2 | Anti-Feline PROCR monoclonal antibody | Feline |
| GM-Tg-cang-MP1406-Ab-1/ GM-Tg-cang-MP1406-Ab-2 | Anti-Canine PROCR monoclonal antibody | Canine |
| GM-Tg-bovg-MP1406-Ab-1/ GM-Tg-bovg-MP1406-Ab-2 | Anti-Bovine PROCR monoclonal antibody | Bovine |
| GM-Tg-equg-MP1406-Ab-1/ GM-Tg-equg-MP1406-Ab-2 | Anti-Equine PROCR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1406-Ab-1/ GM-Tg-hg-MP1406-Ab-2; GM-Tg-rg-MP1406-Ab-1/ GM-Tg-rg-MP1406-Ab-2; GM-Tg-mg-MP1406-Ab-1/ GM-Tg-mg-MP1406-Ab-2; GM-Tg-cynog-MP1406-Ab-1/ GM-Tg-cynog-MP1406-Ab-2; GM-Tg-felg-MP1406-Ab-1/ GM-Tg-felg-MP1406-Ab-2; GM-Tg-cang-MP1406-Ab-1/ GM-Tg-cang-MP1406-Ab-2; GM-Tg-bovg-MP1406-Ab-1/ GM-Tg-bovg-MP1406-Ab-2; GM-Tg-equg-MP1406-Ab-1/ GM-Tg-equg-MP1406-Ab-2 |
| Products Name | Anti-PROCR monoclonal antibody |
| Format | mab |
| Target Name | PROCR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PROCR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EPCR/ PROCR/ CCCA VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP004289 | human PROCR Lentivirus plasmid |
| ORF Viral Vector | vGMLP004289 | human PROCR Lentivirus particle |
| ORF Viral Vector | pGMLPm004177 | mouse Procr Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004177 | mouse Procr Lentivirus particle |
Target information
| Target ID | GM-MP1406 |
| Target Name | PROCR |
| Gene ID | 10544,19124,362248,706040,485848,101082897,282005,100069445 |
| Gene Symbol and Synonyms | CCCA,CCD41,EPCR,PROCR |
| Uniprot Accession | Q9UNN8,Q4V8I1,Q28105 |
| Uniprot Entry Name | EPCR_HUMAN,EPCR_RAT,EPCR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000101000 |
| Target Classification | N/A |
The target: PROCR, gene name: PROCR, also named as CCCA, CCD41, EPCR. The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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