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Anti-SCN1B/ ATFB13/ BRGDA5 monoclonal antibody
Anti-SCN1B/ ATFB13/ BRGDA5 antibody for FACS & in-vivo assay
Go to SCN1B/SCN1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1487-Ab-1/ GM-Tg-hg-MP1487-Ab-2 | Anti-Human SCN1B monoclonal antibody | Human |
| GM-Tg-rg-MP1487-Ab-1/ GM-Tg-rg-MP1487-Ab-2 | Anti-Rat SCN1B monoclonal antibody | Rat |
| GM-Tg-mg-MP1487-Ab-1/ GM-Tg-mg-MP1487-Ab-2 | Anti-Mouse SCN1B monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1487-Ab-1/ GM-Tg-cynog-MP1487-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SCN1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1487-Ab-1/ GM-Tg-felg-MP1487-Ab-2 | Anti-Feline SCN1B monoclonal antibody | Feline |
| GM-Tg-cang-MP1487-Ab-1/ GM-Tg-cang-MP1487-Ab-2 | Anti-Canine SCN1B monoclonal antibody | Canine |
| GM-Tg-bovg-MP1487-Ab-1/ GM-Tg-bovg-MP1487-Ab-2 | Anti-Bovine SCN1B monoclonal antibody | Bovine |
| GM-Tg-equg-MP1487-Ab-1/ GM-Tg-equg-MP1487-Ab-2 | Anti-Equine SCN1B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1487-Ab-1/ GM-Tg-hg-MP1487-Ab-2; GM-Tg-rg-MP1487-Ab-1/ GM-Tg-rg-MP1487-Ab-2; GM-Tg-mg-MP1487-Ab-1/ GM-Tg-mg-MP1487-Ab-2; GM-Tg-cynog-MP1487-Ab-1/ GM-Tg-cynog-MP1487-Ab-2; GM-Tg-felg-MP1487-Ab-1/ GM-Tg-felg-MP1487-Ab-2; GM-Tg-cang-MP1487-Ab-1/ GM-Tg-cang-MP1487-Ab-2; GM-Tg-bovg-MP1487-Ab-1/ GM-Tg-bovg-MP1487-Ab-2; GM-Tg-equg-MP1487-Ab-1/ GM-Tg-equg-MP1487-Ab-2 |
| Products Name | Anti-SCN1B monoclonal antibody |
| Format | mab |
| Target Name | SCN1B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SCN1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SCN1B/ ATFB13/ BRGDA5 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002937 | human SCN1B Lentivirus particle |
| ORF Viral Vector | pGMLP002937 | human SCN1B Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000576 | mouse Scn1b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000576 | mouse Scn1b Lentivirus particle |
Target information
| Target ID | GM-MP1487 |
| Target Name | SCN1B |
| Gene ID | 6324,20266,29686,707134,484584,101101526,618204,100050415 |
| Gene Symbol and Synonyms | ATFB13,BRGDA5,DEE52,EIEE52,GEFSP1,SCN1B |
| Uniprot Accession | Q07699,Q00954,Q4PPC4,Q17QN4 |
| Uniprot Entry Name | SCN1B_HUMAN,SCN1B_RAT,SCN1B_CANLF,SCN1B_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000105711 |
| Target Classification | N/A |
The target: SCN1B, gene name: SCN1B, also named as ATFB13, BRGDA5, EIEE52, GEFSP1. Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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