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Anti-SCN4B/ ATFB17/ LQT10 monoclonal antibody
Anti-SCN4B/ ATFB17/ LQT10 antibody for FACS & in-vivo assay
Go to SCN4B/SCN4B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1490-Ab-1/ GM-Tg-hg-MP1490-Ab-2 | Anti-Human SCN4B monoclonal antibody | Human |
| GM-Tg-rg-MP1490-Ab-1/ GM-Tg-rg-MP1490-Ab-2 | Anti-Rat SCN4B monoclonal antibody | Rat |
| GM-Tg-mg-MP1490-Ab-1/ GM-Tg-mg-MP1490-Ab-2 | Anti-Mouse SCN4B monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1490-Ab-1/ GM-Tg-cynog-MP1490-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SCN4B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1490-Ab-1/ GM-Tg-felg-MP1490-Ab-2 | Anti-Feline SCN4B monoclonal antibody | Feline |
| GM-Tg-cang-MP1490-Ab-1/ GM-Tg-cang-MP1490-Ab-2 | Anti-Canine SCN4B monoclonal antibody | Canine |
| GM-Tg-bovg-MP1490-Ab-1/ GM-Tg-bovg-MP1490-Ab-2 | Anti-Bovine SCN4B monoclonal antibody | Bovine |
| GM-Tg-equg-MP1490-Ab-1/ GM-Tg-equg-MP1490-Ab-2 | Anti-Equine SCN4B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1490-Ab-1/ GM-Tg-hg-MP1490-Ab-2; GM-Tg-rg-MP1490-Ab-1/ GM-Tg-rg-MP1490-Ab-2; GM-Tg-mg-MP1490-Ab-1/ GM-Tg-mg-MP1490-Ab-2; GM-Tg-cynog-MP1490-Ab-1/ GM-Tg-cynog-MP1490-Ab-2; GM-Tg-felg-MP1490-Ab-1/ GM-Tg-felg-MP1490-Ab-2; GM-Tg-cang-MP1490-Ab-1/ GM-Tg-cang-MP1490-Ab-2; GM-Tg-bovg-MP1490-Ab-1/ GM-Tg-bovg-MP1490-Ab-2; GM-Tg-equg-MP1490-Ab-1/ GM-Tg-equg-MP1490-Ab-2 |
| Products Name | Anti-SCN4B monoclonal antibody |
| Format | mab |
| Target Name | SCN4B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SCN4B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SCN4B/ ATFB17/ LQT10 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001845 | human SCN4B Lentivirus plasmid |
| ORF Viral Vector | vGMLP001845 | human SCN4B Lentivirus particle |
| ORF Viral Vector | pGMLPm003698 | mouse Scn4b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003698 | mouse Scn4b Lentivirus particle |
Target information
| Target ID | GM-MP1490 |
| Target Name | SCN4B |
| Gene ID | 6330,399548,315611,100430940,100688178,101087863,538100,100071197 |
| Gene Symbol and Synonyms | ATFB17,Gm1471,LQT10,Navbeta4,SCN4B |
| Uniprot Accession | Q8IWT1,Q7M730,Q08E08 |
| Uniprot Entry Name | SCN4B_HUMAN,SCN4B_RAT,SCN4B_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000177098 |
| Target Classification | N/A |
The target: SCN4B, gene name: SCN4B, also named as ATFB17, LQT10, Navbeta4. The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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