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Anti-S22AI/ SLC22A18/ BWR1A monoclonal antibody
Anti-S22AI/ SLC22A18/ BWR1A antibody for FACS & in-vivo assay
Go to SLC22A18/SLC22A18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1560-Ab-1/ GM-Tg-hg-MP1560-Ab-2 | Anti-Human SLC22A18 monoclonal antibody | Human |
| GM-Tg-rg-MP1560-Ab-1/ GM-Tg-rg-MP1560-Ab-2 | Anti-Rat SLC22A18 monoclonal antibody | Rat |
| GM-Tg-mg-MP1560-Ab-1/ GM-Tg-mg-MP1560-Ab-2 | Anti-Mouse SLC22A18 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1560-Ab-1/ GM-Tg-cynog-MP1560-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC22A18 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1560-Ab-1/ GM-Tg-felg-MP1560-Ab-2 | Anti-Feline SLC22A18 monoclonal antibody | Feline |
| GM-Tg-cang-MP1560-Ab-1/ GM-Tg-cang-MP1560-Ab-2 | Anti-Canine SLC22A18 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1560-Ab-1/ GM-Tg-bovg-MP1560-Ab-2 | Anti-Bovine SLC22A18 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1560-Ab-1/ GM-Tg-equg-MP1560-Ab-2 | Anti-Equine SLC22A18 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1560-Ab-1/ GM-Tg-hg-MP1560-Ab-2; GM-Tg-rg-MP1560-Ab-1/ GM-Tg-rg-MP1560-Ab-2; GM-Tg-mg-MP1560-Ab-1/ GM-Tg-mg-MP1560-Ab-2; GM-Tg-cynog-MP1560-Ab-1/ GM-Tg-cynog-MP1560-Ab-2; GM-Tg-felg-MP1560-Ab-1/ GM-Tg-felg-MP1560-Ab-2; GM-Tg-cang-MP1560-Ab-1/ GM-Tg-cang-MP1560-Ab-2; GM-Tg-bovg-MP1560-Ab-1/ GM-Tg-bovg-MP1560-Ab-2; GM-Tg-equg-MP1560-Ab-1/ GM-Tg-equg-MP1560-Ab-2 |
| Products Name | Anti-SLC22A18 monoclonal antibody |
| Format | mab |
| Target Name | SLC22A18 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC22A18 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S22AI/ SLC22A18/ BWR1A VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003680 | human SLC22A18 Lentivirus particle |
| ORF Viral Vector | pGMLP003680 | human SLC22A18 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001634 | mouse Slc22a18 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001634 | mouse Slc22a18 Lentivirus particle |
Target information
| Target ID | GM-MP1560 |
| Target Name | SLC22A18 |
| Gene ID | 5002,18400,309131,721230,475997,101092398,504885,100060198 |
| Gene Symbol and Synonyms | BWR1A,BWSCR1A,HET,IMPT1,I™,ORCTL2,p45-BWR1A,SLC22A18,SLC22A1L,TSSC5 |
| Uniprot Accession | Q96BI1,Q6AY78 |
| Uniprot Entry Name | S22AI_HUMAN,S22AI_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000110628 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SLC22A18, gene name: SLC22A18, also named as BWR1A, BWSCR1A, HET, IMPT1, I™, ORCTL2, SLC22A1L, TSSC5, p45-BWR1A. This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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