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Anti-S39AE/ SLC39A14/ HCIN monoclonal antibody
Anti-S39AE/ SLC39A14/ HCIN antibody for FACS & in-vivo assay
Go to SLC39A14/SLC39A14 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1615-Ab-1/ GM-Tg-hg-MP1615-Ab-2 | Anti-Human SLC39A14 monoclonal antibody | Human |
| GM-Tg-rg-MP1615-Ab-1/ GM-Tg-rg-MP1615-Ab-2 | Anti-Rat SLC39A14 monoclonal antibody | Rat |
| GM-Tg-mg-MP1615-Ab-1/ GM-Tg-mg-MP1615-Ab-2 | Anti-Mouse SLC39A14 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1615-Ab-1/ GM-Tg-cynog-MP1615-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC39A14 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1615-Ab-1/ GM-Tg-felg-MP1615-Ab-2 | Anti-Feline SLC39A14 monoclonal antibody | Feline |
| GM-Tg-cang-MP1615-Ab-1/ GM-Tg-cang-MP1615-Ab-2 | Anti-Canine SLC39A14 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1615-Ab-1/ GM-Tg-bovg-MP1615-Ab-2 | Anti-Bovine SLC39A14 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1615-Ab-1/ GM-Tg-equg-MP1615-Ab-2 | Anti-Equine SLC39A14 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1615-Ab-1/ GM-Tg-hg-MP1615-Ab-2; GM-Tg-rg-MP1615-Ab-1/ GM-Tg-rg-MP1615-Ab-2; GM-Tg-mg-MP1615-Ab-1/ GM-Tg-mg-MP1615-Ab-2; GM-Tg-cynog-MP1615-Ab-1/ GM-Tg-cynog-MP1615-Ab-2; GM-Tg-felg-MP1615-Ab-1/ GM-Tg-felg-MP1615-Ab-2; GM-Tg-cang-MP1615-Ab-1/ GM-Tg-cang-MP1615-Ab-2; GM-Tg-bovg-MP1615-Ab-1/ GM-Tg-bovg-MP1615-Ab-2; GM-Tg-equg-MP1615-Ab-1/ GM-Tg-equg-MP1615-Ab-2 |
| Products Name | Anti-SLC39A14 monoclonal antibody |
| Format | mab |
| Target Name | SLC39A14 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC39A14 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S39AE/ SLC39A14/ HCIN VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001054 | human SLC39A14 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001054 | human SLC39A14 Lentivirus particle |
| ORF Viral Vector | pGMLPm001537 | mouse Slc39a14 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001537 | mouse Slc39a14 Lentivirus particle |
Target information
| Target ID | GM-MP1615 |
| Target Name | SLC39A14 |
| Gene ID | 23516,213053,306009,716112,486124,101087988,515437 |
| Gene Symbol and Synonyms | cig19,FAD-123,fad123,HCIN,HMNDYT2,LZT-Hs4,NET34,SLC39A14,ZIP-14,ZIP14 |
| Uniprot Accession | Q15043,A5D7L5 |
| Uniprot Entry Name | S39AE_HUMAN,S39AE_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000104635 |
| Target Classification | N/A |
The target: SLC39A14, gene name: SLC39A14, also named as HCIN, HMNDYT2, LZT-Hs4, NET34, ZIP14, cig19. This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
