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Anti-STX1B/ GEFSP91/ STX1B2 monoclonal antibody
Anti-STX1B/ GEFSP91/ STX1B2 antibody for FACS & in-vivo assay
Go to STX1B/STX1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1725-Ab-1/ GM-Tg-hg-MP1725-Ab-2 | Anti-Human STX1B monoclonal antibody | Human |
| GM-Tg-rg-MP1725-Ab-1/ GM-Tg-rg-MP1725-Ab-2 | Anti-Rat STX1B monoclonal antibody | Rat |
| GM-Tg-mg-MP1725-Ab-1/ GM-Tg-mg-MP1725-Ab-2 | Anti-Mouse STX1B monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1725-Ab-1/ GM-Tg-cynog-MP1725-Ab-2 | Anti-Cynomolgus/ Rhesus macaque STX1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1725-Ab-1/ GM-Tg-felg-MP1725-Ab-2 | Anti-Feline STX1B monoclonal antibody | Feline |
| GM-Tg-cang-MP1725-Ab-1/ GM-Tg-cang-MP1725-Ab-2 | Anti-Canine STX1B monoclonal antibody | Canine |
| GM-Tg-bovg-MP1725-Ab-1/ GM-Tg-bovg-MP1725-Ab-2 | Anti-Bovine STX1B monoclonal antibody | Bovine |
| GM-Tg-equg-MP1725-Ab-1/ GM-Tg-equg-MP1725-Ab-2 | Anti-Equine STX1B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1725-Ab-1/ GM-Tg-hg-MP1725-Ab-2; GM-Tg-rg-MP1725-Ab-1/ GM-Tg-rg-MP1725-Ab-2; GM-Tg-mg-MP1725-Ab-1/ GM-Tg-mg-MP1725-Ab-2; GM-Tg-cynog-MP1725-Ab-1/ GM-Tg-cynog-MP1725-Ab-2; GM-Tg-felg-MP1725-Ab-1/ GM-Tg-felg-MP1725-Ab-2; GM-Tg-cang-MP1725-Ab-1/ GM-Tg-cang-MP1725-Ab-2; GM-Tg-bovg-MP1725-Ab-1/ GM-Tg-bovg-MP1725-Ab-2; GM-Tg-equg-MP1725-Ab-1/ GM-Tg-equg-MP1725-Ab-2 |
| Products Name | Anti-STX1B monoclonal antibody |
| Format | mab |
| Target Name | STX1B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-STX1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species STX1B/ GEFSP91/ STX1B2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000968 | human STX1B Lentivirus plasmid |
| ORF Viral Vector | vGMLP000968 | human STX1B Lentivirus particle |
| ORF Viral Vector | pGMLPm001149 | mouse Stx1b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001149 | mouse Stx1b Lentivirus particle |
Target information
| Target ID | GM-MP1725 |
| Target Name | STX1B |
| Gene ID | 112755,56216,24923,714251,489918,101083133,282377,100146591 |
| Gene Symbol and Synonyms | GEFSP9,STX1B,STX1B1,STX1B2,Stx1bl,Stx2,Syn1b |
| Uniprot Accession | P61266,P61265,P61267 |
| Uniprot Entry Name | STX1B_HUMAN,STX1B_RAT,STX1B_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000099365 |
| Target Classification | N/A |
The target: STX1B, gene name: STX1B, also named as GEFSP91, STX1B2, STX1B. The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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