Anti-™EDA/ ™ED10/ P24(DELTA) monoclonal antibody

Anti-™EDA/ ™ED10/ P24(DELTA) antibody for FACS & in-vivo assay

Target products collectionGo to ™ED10/™ED10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1807-Ab-1/ GM-Tg-hg-MP1807-Ab-2Anti-Human ™ED10 monoclonal antibodyHuman
GM-Tg-rg-MP1807-Ab-1/ GM-Tg-rg-MP1807-Ab-2Anti-Rat ™ED10 monoclonal antibodyRat
GM-Tg-mg-MP1807-Ab-1/ GM-Tg-mg-MP1807-Ab-2Anti-Mouse ™ED10 monoclonal antibodyMouse
GM-Tg-cynog-MP1807-Ab-1/ GM-Tg-cynog-MP1807-Ab-2Anti-Cynomolgus/ Rhesus macaque ™ED10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1807-Ab-1/ GM-Tg-felg-MP1807-Ab-2Anti-Feline ™ED10 monoclonal antibodyFeline
GM-Tg-cang-MP1807-Ab-1/ GM-Tg-cang-MP1807-Ab-2Anti-Canine ™ED10 monoclonal antibodyCanine
GM-Tg-bovg-MP1807-Ab-1/ GM-Tg-bovg-MP1807-Ab-2Anti-Bovine ™ED10 monoclonal antibodyBovine
GM-Tg-equg-MP1807-Ab-1/ GM-Tg-equg-MP1807-Ab-2Anti-Equine ™ED10 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1807-Ab-1/ GM-Tg-hg-MP1807-Ab-2; GM-Tg-rg-MP1807-Ab-1/ GM-Tg-rg-MP1807-Ab-2;
GM-Tg-mg-MP1807-Ab-1/ GM-Tg-mg-MP1807-Ab-2; GM-Tg-cynog-MP1807-Ab-1/ GM-Tg-cynog-MP1807-Ab-2;
GM-Tg-felg-MP1807-Ab-1/ GM-Tg-felg-MP1807-Ab-2; GM-Tg-cang-MP1807-Ab-1/ GM-Tg-cang-MP1807-Ab-2;
GM-Tg-bovg-MP1807-Ab-1/ GM-Tg-bovg-MP1807-Ab-2; GM-Tg-equg-MP1807-Ab-1/ GM-Tg-equg-MP1807-Ab-2
Products NameAnti-™ED10 monoclonal antibody
Formatmab
Target Name™ED10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-™ED10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ™EDA/ ™ED10/ P24(DELTA) VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP004242human ™ED10 Lentivirus particle
    ORF Viral VectorpGMAP000155Human ™ED10 Adenovirus plasmid
    ORF Viral VectorvGMAP000155Human ™ED10 Adenovirus particle
    ORF Viral VectorpGMLP004242human ™ED10 Lentivirus plasmid
    ORF Viral VectorpGMLPm003543mouse Tmed10 Lentivirus plasmid
    ORF Viral VectorpGMLPm004872mouse Tmed10 Lentivirus plasmid
    ORF Viral VectorvGMLPm003543mouse Tmed10 Lentivirus particle
    ORF Viral VectorvGMLPm004872mouse Tmed10 Lentivirus particle


    Target information

    Target IDGM-MP1807
    Target Name™ED10
    Gene ID10972,68581,84599,701522,610559,101097492,529761,100051561
    Gene Symbol and Synonyms1110014C03Rik,p23,P24(DELTA),p24d1,p24delta1,S31I125,S31III125,™ED10,Tmp-21-I,™P21
    Uniprot AccessionP49755,Q63584,Q5E971
    Uniprot Entry Name™EDA_HUMAN,™EDA_RAT,™EDA_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000170348
    Target ClassificationN/A

    The target: ™ED10, gene name: ™ED10, also named as P24(DELTA), S31I125, S31III125, ™P21, Tmp-21-I, p23, p24d1. This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.