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Anti-ZP4/ ZBP/ ZP1 monoclonal antibody
Anti-ZP4/ ZBP/ ZP1 antibody for FACS & in-vivo assay
Go to ZP4/ZP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1966-Ab-1/ GM-Tg-hg-MP1966-Ab-2 | Anti-Human ZP4 monoclonal antibody | Human |
| GM-Tg-rg-MP1966-Ab-1/ GM-Tg-rg-MP1966-Ab-2 | Anti-Rat ZP4 monoclonal antibody | Rat |
| GM-Tg-mg-MP1966-Ab-1/ GM-Tg-mg-MP1966-Ab-2 | Anti-Mouse ZP4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1966-Ab-1/ GM-Tg-cynog-MP1966-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ZP4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1966-Ab-1/ GM-Tg-felg-MP1966-Ab-2 | Anti-Feline ZP4 monoclonal antibody | Feline |
| GM-Tg-cang-MP1966-Ab-1/ GM-Tg-cang-MP1966-Ab-2 | Anti-Canine ZP4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1966-Ab-1/ GM-Tg-bovg-MP1966-Ab-2 | Anti-Bovine ZP4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1966-Ab-1/ GM-Tg-equg-MP1966-Ab-2 | Anti-Equine ZP4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1966-Ab-1/ GM-Tg-hg-MP1966-Ab-2; GM-Tg-rg-MP1966-Ab-1/ GM-Tg-rg-MP1966-Ab-2; GM-Tg-mg-MP1966-Ab-1/ GM-Tg-mg-MP1966-Ab-2; GM-Tg-cynog-MP1966-Ab-1/ GM-Tg-cynog-MP1966-Ab-2; GM-Tg-felg-MP1966-Ab-1/ GM-Tg-felg-MP1966-Ab-2; GM-Tg-cang-MP1966-Ab-1/ GM-Tg-cang-MP1966-Ab-2; GM-Tg-bovg-MP1966-Ab-1/ GM-Tg-bovg-MP1966-Ab-2; GM-Tg-equg-MP1966-Ab-1/ GM-Tg-equg-MP1966-Ab-2 |
| Products Name | Anti-ZP4 monoclonal antibody |
| Format | mab |
| Target Name | ZP4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ZP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ZP4/ ZBP/ ZP1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001807 | human ZP4 Lentivirus particle |
| ORF Viral Vector | pGMLP001807 | human ZP4 Lentivirus plasmid |
Target information
| Target ID | GM-MP1966 |
| Target Name | ZP4 |
| Gene ID | 57829,282833,709637,442977,493791,280965,100057402 |
| Gene Symbol and Synonyms | TAC4,ZBP,Zp-4,ZP1,ZP1B,ZP4,ZPB,ZPB2 |
| Uniprot Accession | Q12836,Q8CH34,P48834,Q9BH11 |
| Uniprot Entry Name | ZP4_HUMAN,ZP4_RAT,ZP4_FELCA,ZP4_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000116996 |
| Target Classification | N/A |
The target: ZP4, gene name: ZP4, also named as ZBP, ZP1, ZPB, Zp-4. The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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