Anti-CAVN1/ CAVIN1/ CAVIN monoclonal antibody

Anti-CAVN1/ CAVIN1/ CAVIN antibody for FACS & in-vivo assay

Target products collectionGo to CAVIN1/CAVIN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2033-Ab-1/ GM-Tg-hg-MP2033-Ab-2Anti-Human CAVIN1 monoclonal antibodyHuman
GM-Tg-rg-MP2033-Ab-1/ GM-Tg-rg-MP2033-Ab-2Anti-Rat CAVIN1 monoclonal antibodyRat
GM-Tg-mg-MP2033-Ab-1/ GM-Tg-mg-MP2033-Ab-2Anti-Mouse CAVIN1 monoclonal antibodyMouse
GM-Tg-cynog-MP2033-Ab-1/ GM-Tg-cynog-MP2033-Ab-2Anti-Cynomolgus/ Rhesus macaque CAVIN1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2033-Ab-1/ GM-Tg-felg-MP2033-Ab-2Anti-Feline CAVIN1 monoclonal antibodyFeline
GM-Tg-cang-MP2033-Ab-1/ GM-Tg-cang-MP2033-Ab-2Anti-Canine CAVIN1 monoclonal antibodyCanine
GM-Tg-bovg-MP2033-Ab-1/ GM-Tg-bovg-MP2033-Ab-2Anti-Bovine CAVIN1 monoclonal antibodyBovine
GM-Tg-equg-MP2033-Ab-1/ GM-Tg-equg-MP2033-Ab-2Anti-Equine CAVIN1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2033-Ab-1/ GM-Tg-hg-MP2033-Ab-2; GM-Tg-rg-MP2033-Ab-1/ GM-Tg-rg-MP2033-Ab-2;
GM-Tg-mg-MP2033-Ab-1/ GM-Tg-mg-MP2033-Ab-2; GM-Tg-cynog-MP2033-Ab-1/ GM-Tg-cynog-MP2033-Ab-2;
GM-Tg-felg-MP2033-Ab-1/ GM-Tg-felg-MP2033-Ab-2; GM-Tg-cang-MP2033-Ab-1/ GM-Tg-cang-MP2033-Ab-2;
GM-Tg-bovg-MP2033-Ab-1/ GM-Tg-bovg-MP2033-Ab-2; GM-Tg-equg-MP2033-Ab-1/ GM-Tg-equg-MP2033-Ab-2
Products NameAnti-CAVIN1 monoclonal antibody
Formatmab
Target NameCAVIN1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CAVIN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CAVN1/ CAVIN1/ CAVIN VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP001720human CAVIN1 Lentivirus particle
    ORF Viral VectorpGMLP001720human CAVIN1 Lentivirus plasmid
    ORF Viral VectorpGMLPm001987mouse Cavin1 Lentivirus plasmid
    ORF Viral VectorvGMLPm001987mouse Cavin1 Lentivirus particle


    Target information

    Target IDGM-MP2033
    Target NameCAVIN1
    Gene ID284119,19285,287710,706570,100855435,101096121,538457,100066120
    Gene Symbol and Synonyms2310075E07Rik,Cav-p60,CAVIN,cavin-1,CAVIN1,CGL4,FKSG13,PTRF
    Uniprot AccessionQ6NZI2,P85125
    Uniprot Entry NameCAVN1_HUMAN,CAVN1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseProstate Cancer
    Gene EnsemblENSG00000177469
    Target ClassificationN/A

    The target: CAVIN1, gene name: CAVIN1, also named as CAVIN, CGL4, FKSG13, PTRF, cavin-1. This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.