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Anti-DAB2/ DOC-2/ DOC2 monoclonal antibody
Anti-DAB2/ DOC-2/ DOC2 antibody for FACS & in-vivo assay
Go to DAB2/DAB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2075-Ab-1/ GM-Tg-hg-MP2075-Ab-2 | Anti-Human DAB2 monoclonal antibody | Human |
| GM-Tg-rg-MP2075-Ab-1/ GM-Tg-rg-MP2075-Ab-2 | Anti-Rat DAB2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2075-Ab-1/ GM-Tg-mg-MP2075-Ab-2 | Anti-Mouse DAB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2075-Ab-1/ GM-Tg-cynog-MP2075-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DAB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2075-Ab-1/ GM-Tg-felg-MP2075-Ab-2 | Anti-Feline DAB2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2075-Ab-1/ GM-Tg-cang-MP2075-Ab-2 | Anti-Canine DAB2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2075-Ab-1/ GM-Tg-bovg-MP2075-Ab-2 | Anti-Bovine DAB2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2075-Ab-1/ GM-Tg-equg-MP2075-Ab-2 | Anti-Equine DAB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2075-Ab-1/ GM-Tg-hg-MP2075-Ab-2; GM-Tg-rg-MP2075-Ab-1/ GM-Tg-rg-MP2075-Ab-2; GM-Tg-mg-MP2075-Ab-1/ GM-Tg-mg-MP2075-Ab-2; GM-Tg-cynog-MP2075-Ab-1/ GM-Tg-cynog-MP2075-Ab-2; GM-Tg-felg-MP2075-Ab-1/ GM-Tg-felg-MP2075-Ab-2; GM-Tg-cang-MP2075-Ab-1/ GM-Tg-cang-MP2075-Ab-2; GM-Tg-bovg-MP2075-Ab-1/ GM-Tg-bovg-MP2075-Ab-2; GM-Tg-equg-MP2075-Ab-1/ GM-Tg-equg-MP2075-Ab-2 |
| Products Name | Anti-DAB2 monoclonal antibody |
| Format | mab |
| Target Name | DAB2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DAB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DAB2/ DOC-2/ DOC2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000123 | human DAB2 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000123 | human DAB2 Adenovirus particle |
| ORF Viral Vector | pGMLPm003112 | mouse Dab2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003112 | mouse Dab2 Lentivirus particle |
Target information
| Target ID | GM-MP2075 |
| Target Name | DAB2 |
| Gene ID | 1601,13132,79128,694349,479353,101096539,509221,100066655 |
| Gene Symbol and Synonyms | 5730435J12Rik,D15Wsu122e,D630005B22Rik,DAB2,DOC-2,DOC2,p96 |
| Uniprot Accession | P98082,O88797 |
| Uniprot Entry Name | DAB2_HUMAN,DAB2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000153071 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: DAB2, gene name: DAB2, also named as DOC-2, DOC2. This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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