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Anti-HINT1/ HINT/ NMAN monoclonal antibody
Anti-HINT1/ HINT/ NMAN antibody for FACS & in-vivo assay
Go to HINT1/HINT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2160-Ab-1/ GM-Tg-hg-MP2160-Ab-2 | Anti-Human HINT1 monoclonal antibody | Human |
| GM-Tg-rg-MP2160-Ab-1/ GM-Tg-rg-MP2160-Ab-2 | Anti-Rat HINT1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2160-Ab-1/ GM-Tg-mg-MP2160-Ab-2 | Anti-Mouse HINT1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2160-Ab-1/ GM-Tg-cynog-MP2160-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HINT1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2160-Ab-1/ GM-Tg-felg-MP2160-Ab-2 | Anti-Feline HINT1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2160-Ab-1/ GM-Tg-cang-MP2160-Ab-2 | Anti-Canine HINT1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2160-Ab-1/ GM-Tg-bovg-MP2160-Ab-2 | Anti-Bovine HINT1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2160-Ab-1/ GM-Tg-equg-MP2160-Ab-2 | Anti-Equine HINT1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2160-Ab-1/ GM-Tg-hg-MP2160-Ab-2; GM-Tg-rg-MP2160-Ab-1/ GM-Tg-rg-MP2160-Ab-2; GM-Tg-mg-MP2160-Ab-1/ GM-Tg-mg-MP2160-Ab-2; GM-Tg-cynog-MP2160-Ab-1/ GM-Tg-cynog-MP2160-Ab-2; GM-Tg-felg-MP2160-Ab-1/ GM-Tg-felg-MP2160-Ab-2; GM-Tg-cang-MP2160-Ab-1/ GM-Tg-cang-MP2160-Ab-2; GM-Tg-bovg-MP2160-Ab-1/ GM-Tg-bovg-MP2160-Ab-2; GM-Tg-equg-MP2160-Ab-1/ GM-Tg-equg-MP2160-Ab-2 |
| Products Name | Anti-HINT1 monoclonal antibody |
| Format | mab |
| Target Name | HINT1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HINT1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HINT1/ HINT/ NMAN VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000950 | human HINT1 Lentivirus particle |
| ORF Viral Vector | pGMLP000950 | human HINT1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000255 | mouse Hint1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000255 | mouse Hint1 Lentivirus particle |
Target information
| Target ID | GM-MP2160 |
| Target Name | HINT1 |
| Gene ID | 3094,15254,690660,706083,474667,101083139,327693,100072940 |
| Gene Symbol and Synonyms | HINT,HINT1,Ipk1,NMAN,Pkci,PKCI-1,Prkci,PRKCNH1 |
| Uniprot Accession | P49773,P62959,P62958 |
| Uniprot Entry Name | HINT1_HUMAN,HINT1_RAT,HINT1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Type 2 diabetes mellitus |
| Gene Ensembl | ENSG00000169567 |
| Target Classification | N/A |
The target: HINT1, gene name: HINT1, also named as HINT, NMAN, PKCI-1, PRKCNH1. This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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