Anti-LEG4/ LGALS4/ GAL4 monoclonal antibody

Anti-LEG4/ LGALS4/ GAL4 antibody for FACS & in-vivo assay

Target products collectionGo to LGALS4/LGALS4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2184-Ab-1/ GM-Tg-hg-MP2184-Ab-2Anti-Human LGALS4 monoclonal antibodyHuman
GM-Tg-rg-MP2184-Ab-1/ GM-Tg-rg-MP2184-Ab-2Anti-Rat LGALS4 monoclonal antibodyRat
GM-Tg-mg-MP2184-Ab-1/ GM-Tg-mg-MP2184-Ab-2Anti-Mouse LGALS4 monoclonal antibodyMouse
GM-Tg-cynog-MP2184-Ab-1/ GM-Tg-cynog-MP2184-Ab-2Anti-Cynomolgus/ Rhesus macaque LGALS4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2184-Ab-1/ GM-Tg-felg-MP2184-Ab-2Anti-Feline LGALS4 monoclonal antibodyFeline
GM-Tg-cang-MP2184-Ab-1/ GM-Tg-cang-MP2184-Ab-2Anti-Canine LGALS4 monoclonal antibodyCanine
GM-Tg-bovg-MP2184-Ab-1/ GM-Tg-bovg-MP2184-Ab-2Anti-Bovine LGALS4 monoclonal antibodyBovine
GM-Tg-equg-MP2184-Ab-1/ GM-Tg-equg-MP2184-Ab-2Anti-Equine LGALS4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2184-Ab-1/ GM-Tg-hg-MP2184-Ab-2; GM-Tg-rg-MP2184-Ab-1/ GM-Tg-rg-MP2184-Ab-2;
GM-Tg-mg-MP2184-Ab-1/ GM-Tg-mg-MP2184-Ab-2; GM-Tg-cynog-MP2184-Ab-1/ GM-Tg-cynog-MP2184-Ab-2;
GM-Tg-felg-MP2184-Ab-1/ GM-Tg-felg-MP2184-Ab-2; GM-Tg-cang-MP2184-Ab-1/ GM-Tg-cang-MP2184-Ab-2;
GM-Tg-bovg-MP2184-Ab-1/ GM-Tg-bovg-MP2184-Ab-2; GM-Tg-equg-MP2184-Ab-1/ GM-Tg-equg-MP2184-Ab-2
Products NameAnti-LGALS4 monoclonal antibody
Formatmab
Target NameLGALS4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LGALS4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LEG4/ LGALS4/ GAL4 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP004495human LGALS4 Lentivirus particle
    ORF Viral VectorpGMLP004495human LGALS4 Lentivirus plasmid
    ORF Viral VectorpGMLPm000876mouse Lgals4 Lentivirus plasmid
    ORF Viral VectorvGMLPm000876mouse Lgals4 Lentivirus particle


    Target information

    Target IDGM-MP2184
    Target NameLGALS4
    Gene ID3960,16855,25474,694195,101100170,614804,100064337
    Gene Symbol and Synonymsgal-4,GAL4,L-36,L36LBI,L36LBP,LGALS4
    Uniprot AccessionP56470,P38552,Q3T0D6
    Uniprot Entry NameLEG4_HUMAN,LEG4_RAT,LEG4_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000171747
    Target ClassificationTumor-associated antigen (TAA)

    The target: LGALS4, gene name: LGALS4, also named as GAL4, L36LBP. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.