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Anti-LZTS2/ LAPSER1 monoclonal antibody
Anti-LZTS2/ LAPSER1 antibody for FACS & in-vivo assay
Go to LZTS2/LZTS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2190-Ab-1/ GM-Tg-hg-MP2190-Ab-2 | Anti-Human LZTS2 monoclonal antibody | Human |
| GM-Tg-rg-MP2190-Ab-1/ GM-Tg-rg-MP2190-Ab-2 | Anti-Rat LZTS2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2190-Ab-1/ GM-Tg-mg-MP2190-Ab-2 | Anti-Mouse LZTS2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2190-Ab-1/ GM-Tg-cynog-MP2190-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LZTS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2190-Ab-1/ GM-Tg-felg-MP2190-Ab-2 | Anti-Feline LZTS2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2190-Ab-1/ GM-Tg-cang-MP2190-Ab-2 | Anti-Canine LZTS2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2190-Ab-1/ GM-Tg-bovg-MP2190-Ab-2 | Anti-Bovine LZTS2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2190-Ab-1/ GM-Tg-equg-MP2190-Ab-2 | Anti-Equine LZTS2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2190-Ab-1/ GM-Tg-hg-MP2190-Ab-2; GM-Tg-rg-MP2190-Ab-1/ GM-Tg-rg-MP2190-Ab-2; GM-Tg-mg-MP2190-Ab-1/ GM-Tg-mg-MP2190-Ab-2; GM-Tg-cynog-MP2190-Ab-1/ GM-Tg-cynog-MP2190-Ab-2; GM-Tg-felg-MP2190-Ab-1/ GM-Tg-felg-MP2190-Ab-2; GM-Tg-cang-MP2190-Ab-1/ GM-Tg-cang-MP2190-Ab-2; GM-Tg-bovg-MP2190-Ab-1/ GM-Tg-bovg-MP2190-Ab-2; GM-Tg-equg-MP2190-Ab-1/ GM-Tg-equg-MP2190-Ab-2 |
| Products Name | Anti-LZTS2 monoclonal antibody |
| Format | mab |
| Target Name | LZTS2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LZTS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LZTS2/ LAPSER1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003811 | human LZTS2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003811 | human LZTS2 Lentivirus particle |
Target information
| Target ID | GM-MP2190 |
| Target Name | LZTS2 |
| Gene ID | 84445,226154,365468,711279,486846,101094378,504411,100060415 |
| Gene Symbol and Synonyms | LAPSER1,LZTS2,mKIAA1813 |
| Uniprot Accession | Q9BRK4,Q3LUD4,A5PKL7 |
| Uniprot Entry Name | LZTS2_HUMAN,LZTS2_RAT,LZTS2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000107816 |
| Target Classification | N/A |
The target: LZTS2, gene name: LZTS2, also named as LAPSER1. The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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