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Anti-PLS1/ PLSCR1/ MMTRA1B monoclonal antibody
Anti-PLS1/ PLSCR1/ MMTRA1B antibody for FACS & in-vivo assay
Go to PLSCR1/PLSCR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2255-Ab-1/ GM-Tg-hg-MP2255-Ab-2 | Anti-Human PLSCR1 monoclonal antibody | Human |
| GM-Tg-rg-MP2255-Ab-1/ GM-Tg-rg-MP2255-Ab-2 | Anti-Rat PLSCR1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2255-Ab-1/ GM-Tg-mg-MP2255-Ab-2 | Anti-Mouse PLSCR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2255-Ab-1/ GM-Tg-cynog-MP2255-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLSCR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2255-Ab-1/ GM-Tg-felg-MP2255-Ab-2 | Anti-Feline PLSCR1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2255-Ab-1/ GM-Tg-cang-MP2255-Ab-2 | Anti-Canine PLSCR1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2255-Ab-1/ GM-Tg-bovg-MP2255-Ab-2 | Anti-Bovine PLSCR1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2255-Ab-1/ GM-Tg-equg-MP2255-Ab-2 | Anti-Equine PLSCR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2255-Ab-1/ GM-Tg-hg-MP2255-Ab-2; GM-Tg-rg-MP2255-Ab-1/ GM-Tg-rg-MP2255-Ab-2; GM-Tg-mg-MP2255-Ab-1/ GM-Tg-mg-MP2255-Ab-2; GM-Tg-cynog-MP2255-Ab-1/ GM-Tg-cynog-MP2255-Ab-2; GM-Tg-felg-MP2255-Ab-1/ GM-Tg-felg-MP2255-Ab-2; GM-Tg-cang-MP2255-Ab-1/ GM-Tg-cang-MP2255-Ab-2; GM-Tg-bovg-MP2255-Ab-1/ GM-Tg-bovg-MP2255-Ab-2; GM-Tg-equg-MP2255-Ab-1/ GM-Tg-equg-MP2255-Ab-2 |
| Products Name | Anti-PLSCR1 monoclonal antibody |
| Format | mab |
| Target Name | PLSCR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLSCR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PLS1/ PLSCR1/ MMTRA1B VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAP000167 | Human PLSCR1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000167 | Human PLSCR1 Adenovirus particle |
| ORF Viral Vector | pGMLPm000875 | mouse Plscr1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000875 | mouse Plscr1 Lentivirus particle |
Target information
| Target ID | GM-MP2255 |
| Target Name | PLSCR1 |
| Gene ID | 5359,100051043 |
| Gene Symbol and Synonyms | MMTRA1B,PLSCR1 |
| Uniprot Accession | O15162 |
| Uniprot Entry Name | PLS1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000188313 |
| Target Classification | N/A |
The target: PLSCR1, gene name: PLSCR1, also named as MMTRA1B. This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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