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Anti-PP1B/ PPP1CB/ HEL-S-80p monoclonal antibody
Anti-PP1B/ PPP1CB/ HEL-S-80p antibody for FACS & in-vivo assay
Go to PPP1CB/PPP1CB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2262-Ab-1/ GM-Tg-hg-MP2262-Ab-2 | Anti-Human PPP1CB monoclonal antibody | Human |
| GM-Tg-rg-MP2262-Ab-1/ GM-Tg-rg-MP2262-Ab-2 | Anti-Rat PPP1CB monoclonal antibody | Rat |
| GM-Tg-mg-MP2262-Ab-1/ GM-Tg-mg-MP2262-Ab-2 | Anti-Mouse PPP1CB monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2262-Ab-1/ GM-Tg-cynog-MP2262-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPP1CB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2262-Ab-1/ GM-Tg-felg-MP2262-Ab-2 | Anti-Feline PPP1CB monoclonal antibody | Feline |
| GM-Tg-cang-MP2262-Ab-1/ GM-Tg-cang-MP2262-Ab-2 | Anti-Canine PPP1CB monoclonal antibody | Canine |
| GM-Tg-bovg-MP2262-Ab-1/ GM-Tg-bovg-MP2262-Ab-2 | Anti-Bovine PPP1CB monoclonal antibody | Bovine |
| GM-Tg-equg-MP2262-Ab-1/ GM-Tg-equg-MP2262-Ab-2 | Anti-Equine PPP1CB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2262-Ab-1/ GM-Tg-hg-MP2262-Ab-2; GM-Tg-rg-MP2262-Ab-1/ GM-Tg-rg-MP2262-Ab-2; GM-Tg-mg-MP2262-Ab-1/ GM-Tg-mg-MP2262-Ab-2; GM-Tg-cynog-MP2262-Ab-1/ GM-Tg-cynog-MP2262-Ab-2; GM-Tg-felg-MP2262-Ab-1/ GM-Tg-felg-MP2262-Ab-2; GM-Tg-cang-MP2262-Ab-1/ GM-Tg-cang-MP2262-Ab-2; GM-Tg-bovg-MP2262-Ab-1/ GM-Tg-bovg-MP2262-Ab-2; GM-Tg-equg-MP2262-Ab-1/ GM-Tg-equg-MP2262-Ab-2 |
| Products Name | Anti-PPP1CB monoclonal antibody |
| Format | mab |
| Target Name | PPP1CB |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PPP1CB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PP1B/ PPP1CB/ HEL-S-80p VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002269 | human PPP1CB Lentivirus particle |
| ORF Viral Vector | pGMLP002269 | human PPP1CB Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001238 | mouse Ppp1cb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001238 | mouse Ppp1cb Lentivirus particle |
Target information
| Target ID | GM-MP2262 |
| Target Name | PPP1CB |
| Gene ID | 5500,19046,25594,703302,403558,101092932,538829,100071067 |
| Gene Symbol and Synonyms | 1200010B19,HEL-S-80p,MP,NSLH2,PP-1B,PP1B,PP1beta,PP1c,PPP1beta,PPP1CB,PPP1CD |
| Uniprot Accession | P62140,P62142,Q8MJ47,Q3SWW9 |
| Uniprot Entry Name | PP1B_HUMAN,PP1B_RAT,PP1B_CANLF,PP1B_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000213639 |
| Target Classification | N/A |
The target: PPP1CB, gene name: PPP1CB, also named as HEL-S-80p, NSLH2, PP-1B, PP1B, PP1beta, PPP1CD. The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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