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Anti-RAPSN/ CMS11/ CMS4C monoclonal antibody
Anti-RAPSN/ CMS11/ CMS4C antibody for FACS & in-vivo assay
Go to RAPSN/RAPSN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2281-Ab-1/ GM-Tg-hg-MP2281-Ab-2 | Anti-Human RAPSN monoclonal antibody | Human |
| GM-Tg-rg-MP2281-Ab-1/ GM-Tg-rg-MP2281-Ab-2 | Anti-Rat RAPSN monoclonal antibody | Rat |
| GM-Tg-mg-MP2281-Ab-1/ GM-Tg-mg-MP2281-Ab-2 | Anti-Mouse RAPSN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2281-Ab-1/ GM-Tg-cynog-MP2281-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RAPSN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2281-Ab-1/ GM-Tg-felg-MP2281-Ab-2 | Anti-Feline RAPSN monoclonal antibody | Feline |
| GM-Tg-cang-MP2281-Ab-1/ GM-Tg-cang-MP2281-Ab-2 | Anti-Canine RAPSN monoclonal antibody | Canine |
| GM-Tg-bovg-MP2281-Ab-1/ GM-Tg-bovg-MP2281-Ab-2 | Anti-Bovine RAPSN monoclonal antibody | Bovine |
| GM-Tg-equg-MP2281-Ab-1/ GM-Tg-equg-MP2281-Ab-2 | Anti-Equine RAPSN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2281-Ab-1/ GM-Tg-hg-MP2281-Ab-2; GM-Tg-rg-MP2281-Ab-1/ GM-Tg-rg-MP2281-Ab-2; GM-Tg-mg-MP2281-Ab-1/ GM-Tg-mg-MP2281-Ab-2; GM-Tg-cynog-MP2281-Ab-1/ GM-Tg-cynog-MP2281-Ab-2; GM-Tg-felg-MP2281-Ab-1/ GM-Tg-felg-MP2281-Ab-2; GM-Tg-cang-MP2281-Ab-1/ GM-Tg-cang-MP2281-Ab-2; GM-Tg-bovg-MP2281-Ab-1/ GM-Tg-bovg-MP2281-Ab-2; GM-Tg-equg-MP2281-Ab-1/ GM-Tg-equg-MP2281-Ab-2 |
| Products Name | Anti-RAPSN monoclonal antibody |
| Format | mab |
| Target Name | RAPSN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RAPSN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RAPSN/ CMS11/ CMS4C VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002983 | human RAPSN Lentivirus particle |
| ORF Viral Vector | pGMLP002983 | human RAPSN Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004920 | mouse Rapsn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004920 | mouse Rapsn Lentivirus particle |
Target information
| Target ID | GM-MP2281 |
| Target Name | RAPSN |
| Gene ID | 5913,19400,362161,711689,609725,101095679,541061,100051540 |
| Gene Symbol and Synonyms | 43kDa,CMS11,CMS4C,FADS,FADS2,Nraps,Raps,RAPSN,RAPSYN,RNF205 |
| Uniprot Accession | Q13702 |
| Uniprot Entry Name | RAPSN_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000165917 |
| Target Classification | N/A |
The target: RAPSN, gene name: RAPSN, also named as CMS11, CMS4C, FADS, RAPSYN, RNF205. This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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