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Anti-RASD1/ AGS1/ DEXRAS1 monoclonal antibody
Anti-RASD1/ AGS1/ DEXRAS1 antibody for FACS & in-vivo assay
Go to RASD1/RASD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2284-Ab-1/ GM-Tg-hg-MP2284-Ab-2 | Anti-Human RASD1 monoclonal antibody | Human |
| GM-Tg-rg-MP2284-Ab-1/ GM-Tg-rg-MP2284-Ab-2 | Anti-Rat RASD1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2284-Ab-1/ GM-Tg-mg-MP2284-Ab-2 | Anti-Mouse RASD1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2284-Ab-1/ GM-Tg-cynog-MP2284-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RASD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2284-Ab-1/ GM-Tg-felg-MP2284-Ab-2 | Anti-Feline RASD1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2284-Ab-1/ GM-Tg-cang-MP2284-Ab-2 | Anti-Canine RASD1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2284-Ab-1/ GM-Tg-bovg-MP2284-Ab-2 | Anti-Bovine RASD1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2284-Ab-1/ GM-Tg-equg-MP2284-Ab-2 | Anti-Equine RASD1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2284-Ab-1/ GM-Tg-hg-MP2284-Ab-2; GM-Tg-rg-MP2284-Ab-1/ GM-Tg-rg-MP2284-Ab-2; GM-Tg-mg-MP2284-Ab-1/ GM-Tg-mg-MP2284-Ab-2; GM-Tg-cynog-MP2284-Ab-1/ GM-Tg-cynog-MP2284-Ab-2; GM-Tg-felg-MP2284-Ab-1/ GM-Tg-felg-MP2284-Ab-2; GM-Tg-cang-MP2284-Ab-1/ GM-Tg-cang-MP2284-Ab-2; GM-Tg-bovg-MP2284-Ab-1/ GM-Tg-bovg-MP2284-Ab-2; GM-Tg-equg-MP2284-Ab-1/ GM-Tg-equg-MP2284-Ab-2 |
| Products Name | Anti-RASD1 monoclonal antibody |
| Format | mab |
| Target Name | RASD1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RASD1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RASD1/ AGS1/ DEXRAS1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002248 | human RASD1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002248 | human RASD1 Lentivirus particle |
| ORF Viral Vector | pGMLPm000648 | mouse Rasd1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000648 | mouse Rasd1 Lentivirus particle |
Target information
| Target ID | GM-MP2284 |
| Target Name | RASD1 |
| Gene ID | 51655,19416,64455,698839,489542,101080588,507449,100146638 |
| Gene Symbol and Synonyms | AGS1,DEXRAS1,MGC:26290,RASD1 |
| Uniprot Accession | Q9Y272,Q9JKF8 |
| Uniprot Entry Name | RASD1_HUMAN,RASD1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000108551 |
| Target Classification | N/A |
The target: RASD1, gene name: RASD1, also named as AGS1, DEXRAS1, MGC:26290. This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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