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Anti-UBE2B/ E2-17kDa/ HHR6B monoclonal antibody
Anti-UBE2B/ E2-17kDa/ HHR6B antibody for FACS & in-vivo assay
Go to UBE2B/UBE2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2371-Ab-1/ GM-Tg-hg-MP2371-Ab-2 | Anti-Human UBE2B monoclonal antibody | Human |
| GM-Tg-rg-MP2371-Ab-1/ GM-Tg-rg-MP2371-Ab-2 | Anti-Rat UBE2B monoclonal antibody | Rat |
| GM-Tg-mg-MP2371-Ab-1/ GM-Tg-mg-MP2371-Ab-2 | Anti-Mouse UBE2B monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2371-Ab-1/ GM-Tg-cynog-MP2371-Ab-2 | Anti-Cynomolgus/ Rhesus macaque UBE2B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2371-Ab-1/ GM-Tg-felg-MP2371-Ab-2 | Anti-Feline UBE2B monoclonal antibody | Feline |
| GM-Tg-cang-MP2371-Ab-1/ GM-Tg-cang-MP2371-Ab-2 | Anti-Canine UBE2B monoclonal antibody | Canine |
| GM-Tg-bovg-MP2371-Ab-1/ GM-Tg-bovg-MP2371-Ab-2 | Anti-Bovine UBE2B monoclonal antibody | Bovine |
| GM-Tg-equg-MP2371-Ab-1/ GM-Tg-equg-MP2371-Ab-2 | Anti-Equine UBE2B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2371-Ab-1/ GM-Tg-hg-MP2371-Ab-2; GM-Tg-rg-MP2371-Ab-1/ GM-Tg-rg-MP2371-Ab-2; GM-Tg-mg-MP2371-Ab-1/ GM-Tg-mg-MP2371-Ab-2; GM-Tg-cynog-MP2371-Ab-1/ GM-Tg-cynog-MP2371-Ab-2; GM-Tg-felg-MP2371-Ab-1/ GM-Tg-felg-MP2371-Ab-2; GM-Tg-cang-MP2371-Ab-1/ GM-Tg-cang-MP2371-Ab-2; GM-Tg-bovg-MP2371-Ab-1/ GM-Tg-bovg-MP2371-Ab-2; GM-Tg-equg-MP2371-Ab-1/ GM-Tg-equg-MP2371-Ab-2 |
| Products Name | Anti-UBE2B monoclonal antibody |
| Format | mab |
| Target Name | UBE2B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-UBE2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species UBE2B/ E2-17kDa/ HHR6B VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000343 | human UBE2B Lentivirus particle |
| ORF Viral Vector | pGMLP000343 | human UBE2B Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000231 | mouse Ube2b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000231 | mouse Ube2b Lentivirus particle |
Target information
| Target ID | GM-MP2371 |
| Target Name | UBE2B |
| Gene ID | 7320,22210,81816,710678,474683,101099525,512207,100062920 |
| Gene Symbol and Synonyms | E2-14k,E2-17kDa,E214K,HHR6B,HR6B,mHR6B,RAD6B,UBC2,UBE2B |
| Uniprot Accession | P63146,P63149,Q32P99 |
| Uniprot Entry Name | UBE2B_HUMAN,UBE2B_RAT,UBE2B_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000119048 |
| Target Classification | N/A |
The target: UBE2B, gene name: UBE2B, also named as E2-17kDa, HHR6B, HR6B, RAD6B, UBC2. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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