- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-DHH/ GDXYM/ HHG-3 monoclonal antibody
Anti-DHH/ GDXYM/ HHG-3 antibody for FACS & in-vivo assay
Go to DHH/DHH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2431-Ab-1/ GM-Tg-hg-MP2431-Ab-2 | Anti-Human DHH monoclonal antibody | Human |
| GM-Tg-rg-MP2431-Ab-1/ GM-Tg-rg-MP2431-Ab-2 | Anti-Rat DHH monoclonal antibody | Rat |
| GM-Tg-mg-MP2431-Ab-1/ GM-Tg-mg-MP2431-Ab-2 | Anti-Mouse DHH monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2431-Ab-1/ GM-Tg-cynog-MP2431-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DHH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2431-Ab-1/ GM-Tg-felg-MP2431-Ab-2 | Anti-Feline DHH monoclonal antibody | Feline |
| GM-Tg-cang-MP2431-Ab-1/ GM-Tg-cang-MP2431-Ab-2 | Anti-Canine DHH monoclonal antibody | Canine |
| GM-Tg-bovg-MP2431-Ab-1/ GM-Tg-bovg-MP2431-Ab-2 | Anti-Bovine DHH monoclonal antibody | Bovine |
| GM-Tg-equg-MP2431-Ab-1/ GM-Tg-equg-MP2431-Ab-2 | Anti-Equine DHH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2431-Ab-1/ GM-Tg-hg-MP2431-Ab-2; GM-Tg-rg-MP2431-Ab-1/ GM-Tg-rg-MP2431-Ab-2; GM-Tg-mg-MP2431-Ab-1/ GM-Tg-mg-MP2431-Ab-2; GM-Tg-cynog-MP2431-Ab-1/ GM-Tg-cynog-MP2431-Ab-2; GM-Tg-felg-MP2431-Ab-1/ GM-Tg-felg-MP2431-Ab-2; GM-Tg-cang-MP2431-Ab-1/ GM-Tg-cang-MP2431-Ab-2; GM-Tg-bovg-MP2431-Ab-1/ GM-Tg-bovg-MP2431-Ab-2; GM-Tg-equg-MP2431-Ab-1/ GM-Tg-equg-MP2431-Ab-2 |
| Products Name | Anti-DHH monoclonal antibody |
| Format | mab |
| Target Name | DHH |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DHH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DHH/ GDXYM/ HHG-3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001485 | human DHH Lentivirus particle |
| ORF Viral Vector | pGMLP001485 | human DHH Lentivirus plasmid |
Target information
| Target ID | GM-MP2431 |
| Target Name | DHH |
| Gene ID | 50846,13363,84380,711048,100685337,101095751,525833,100059016 |
| Gene Symbol and Synonyms | DHH,GDMN,GDXYM,HHG-3,SRXY7 |
| Uniprot Accession | O43323 |
| Uniprot Entry Name | DHH_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000139549 |
| Target Classification | N/A |
The target: DHH, gene name: DHH, also named as GDXYM, HHG-3, SRXY7. This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
