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Anti-FKRP/ LGMD2I/ LGMDR9 functional antibody
Anti-FKRP/ LGMD2I/ LGMDR9 functional antibody for cell culture, ELISA & in-vivo assay
Go to FKRP/FKRP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0222-Ab-1/ GM-Tg-hg-SE0222-Ab-2 | Anti-Human FKRP monoclonal antibody | Human |
| GM-Tg-rg-SE0222-Ab-1/ GM-Tg-rg-SE0222-Ab-2 | Anti-Rat FKRP monoclonal antibody | Rat |
| GM-Tg-mg-SE0222-Ab-1/ GM-Tg-mg-SE0222-Ab-2 | Anti-Mouse FKRP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0222-Ab-1/ GM-Tg-cynog-SE0222-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FKRP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0222-Ab-1/ GM-Tg-felg-SE0222-Ab-2 | Anti-Feline FKRP monoclonal antibody | Feline |
| GM-Tg-cang-SE0222-Ab-1/ GM-Tg-cang-SE0222-Ab-2 | Anti-Canine FKRP monoclonal antibody | Canine |
| GM-Tg-bovg-SE0222-Ab-1/ GM-Tg-bovg-SE0222-Ab-2 | Anti-Bovine FKRP monoclonal antibody | Bovine |
| GM-Tg-equg-SE0222-Ab-1/ GM-Tg-equg-SE0222-Ab-2 | Anti-Equine FKRP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0222-Ab-1/ GM-Tg-hg-SE0222-Ab-2; GM-Tg-rg-SE0222-Ab-1/ GM-Tg-rg-SE0222-Ab-2; GM-Tg-mg-SE0222-Ab-1/ GM-Tg-mg-SE0222-Ab-2; GM-Tg-cynog-SE0222-Ab-1/ GM-Tg-cynog-SE0222-Ab-2; GM-Tg-felg-SE0222-Ab-1/ GM-Tg-felg-SE0222-Ab-2; GM-Tg-cang-SE0222-Ab-1/ GM-Tg-cang-SE0222-Ab-2; GM-Tg-bovg-SE0222-Ab-1/ GM-Tg-bovg-SE0222-Ab-2; GM-Tg-equg-SE0222-Ab-1/ GM-Tg-equg-SE0222-Ab-2 |
| Products Name | Anti-FKRP monoclonal antibody |
| Format | mab |
| Target Name | FKRP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FKRP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0222-Ag-1 | Recombinant multi-species FKRP/ LGMD2I/ LGMDR9 protein |
| ORF Viral Vector | pGMLP001501 | human FKRP Lentivirus plasmid |
| ORF Viral Vector | vGMLP001501 | human FKRP Lentivirus particle |
| ORF Viral Vector | pGMLPm003844 | mouse Fkrp Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003844 | mouse Fkrp Lentivirus particle |
Target information
| Target ID | GM-SE0222 |
| Target Name | FKRP |
| Gene ID | 79147,243853,308390,716804,484426,101099604,539701,102148152 |
| Gene Symbol and Synonyms | A830029B19Rik,FKRP,FKTR,LGMD1I,LGMD2I,LGMDR9,MDC1C,MDDGA5,MDDGB5,MDDGC5 |
| Uniprot Accession | Q9H9S5 |
| Uniprot Entry Name | FKRP_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000181027 |
| Target Classification | N/A |
The target: FKRP, gene name: FKRP, also named as LGMD2I, LGMDR9, MDC1C, MDDGA5, MDDGB5, MDDGC5. This gene encodes a protein which is targeted to the medial Golgi apparatus and is necessary for posttranslational modification of dystroglycan. Mutations in this gene have been associated with congenital muscular dystrophy, cognitive disability, and cerebellar cysts. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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