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Anti-MEST/ PEG1 functional antibody
Anti-MEST/ PEG1 functional antibody for cell culture, ELISA & in-vivo assay
Go to MEST/MEST products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0338-Ab-1/ GM-Tg-hg-SE0338-Ab-2 | Anti-Human MEST monoclonal antibody | Human |
| GM-Tg-rg-SE0338-Ab-1/ GM-Tg-rg-SE0338-Ab-2 | Anti-Rat MEST monoclonal antibody | Rat |
| GM-Tg-mg-SE0338-Ab-1/ GM-Tg-mg-SE0338-Ab-2 | Anti-Mouse MEST monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0338-Ab-1/ GM-Tg-cynog-SE0338-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MEST monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0338-Ab-1/ GM-Tg-felg-SE0338-Ab-2 | Anti-Feline MEST monoclonal antibody | Feline |
| GM-Tg-cang-SE0338-Ab-1/ GM-Tg-cang-SE0338-Ab-2 | Anti-Canine MEST monoclonal antibody | Canine |
| GM-Tg-bovg-SE0338-Ab-1/ GM-Tg-bovg-SE0338-Ab-2 | Anti-Bovine MEST monoclonal antibody | Bovine |
| GM-Tg-equg-SE0338-Ab-1/ GM-Tg-equg-SE0338-Ab-2 | Anti-Equine MEST monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0338-Ab-1/ GM-Tg-hg-SE0338-Ab-2; GM-Tg-rg-SE0338-Ab-1/ GM-Tg-rg-SE0338-Ab-2; GM-Tg-mg-SE0338-Ab-1/ GM-Tg-mg-SE0338-Ab-2; GM-Tg-cynog-SE0338-Ab-1/ GM-Tg-cynog-SE0338-Ab-2; GM-Tg-felg-SE0338-Ab-1/ GM-Tg-felg-SE0338-Ab-2; GM-Tg-cang-SE0338-Ab-1/ GM-Tg-cang-SE0338-Ab-2; GM-Tg-bovg-SE0338-Ab-1/ GM-Tg-bovg-SE0338-Ab-2; GM-Tg-equg-SE0338-Ab-1/ GM-Tg-equg-SE0338-Ab-2 |
| Products Name | Anti-MEST monoclonal antibody |
| Format | mab |
| Target Name | MEST |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MEST benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0338-Ag-1 | Recombinant multi-species MEST/ PEG1 protein |
| ORF Viral Vector | vGMLP003018 | human MEST Lentivirus particle |
| ORF Viral Vector | pGMLP003018 | human MEST Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002542 | mouse Mest Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002542 | mouse Mest Lentivirus particle |
Target information
| Target ID | GM-SE0338 |
| Target Name | MEST |
| Gene ID | 4232,17294,58827,703327,607717,101091182,404180,100057213 |
| Gene Symbol and Synonyms | MEST,PEG1 |
| Uniprot Accession | Q5EB52,Q6P5P5,Q2HJM9 |
| Uniprot Entry Name | MEST_HUMAN,MEST_RAT,MEST_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000106484 |
| Target Classification | N/A |
The target: MEST, gene name: MEST, also named as PEG1. This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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