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Anti-I36RA/ IL36RN/ FIL1 functional antibody
Anti-I36RA/ IL36RN/ FIL1 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL36RN/IL36RN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0627-Ab-1/ GM-Tg-hg-SE0627-Ab-2 | Anti-Human IL36RN monoclonal antibody | Human |
| GM-Tg-rg-SE0627-Ab-1/ GM-Tg-rg-SE0627-Ab-2 | Anti-Rat IL36RN monoclonal antibody | Rat |
| GM-Tg-mg-SE0627-Ab-1/ GM-Tg-mg-SE0627-Ab-2 | Anti-Mouse IL36RN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0627-Ab-1/ GM-Tg-cynog-SE0627-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL36RN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0627-Ab-1/ GM-Tg-felg-SE0627-Ab-2 | Anti-Feline IL36RN monoclonal antibody | Feline |
| GM-Tg-cang-SE0627-Ab-1/ GM-Tg-cang-SE0627-Ab-2 | Anti-Canine IL36RN monoclonal antibody | Canine |
| GM-Tg-bovg-SE0627-Ab-1/ GM-Tg-bovg-SE0627-Ab-2 | Anti-Bovine IL36RN monoclonal antibody | Bovine |
| GM-Tg-equg-SE0627-Ab-1/ GM-Tg-equg-SE0627-Ab-2 | Anti-Equine IL36RN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0627-Ab-1/ GM-Tg-hg-SE0627-Ab-2; GM-Tg-rg-SE0627-Ab-1/ GM-Tg-rg-SE0627-Ab-2; GM-Tg-mg-SE0627-Ab-1/ GM-Tg-mg-SE0627-Ab-2; GM-Tg-cynog-SE0627-Ab-1/ GM-Tg-cynog-SE0627-Ab-2; GM-Tg-felg-SE0627-Ab-1/ GM-Tg-felg-SE0627-Ab-2; GM-Tg-cang-SE0627-Ab-1/ GM-Tg-cang-SE0627-Ab-2; GM-Tg-bovg-SE0627-Ab-1/ GM-Tg-bovg-SE0627-Ab-2; GM-Tg-equg-SE0627-Ab-1/ GM-Tg-equg-SE0627-Ab-2 |
| Products Name | Anti-IL36RN monoclonal antibody |
| Format | mab |
| Target Name | IL36RN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL36RN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-532 | Pre-Made Spesolimab biosimilar, Whole mAb, Anti-IL36RN/IL-36R Antibody: Anti-FIL1/FIL1(DELTA)/FIL1D/IL1F5/IL1HY1/IL1L1/IL1RP3/IL36RA/PSORP/PSORS14 therapeutic antibody |
| Target Antigen | GM-Tg-g-SE0627-Ag-1 | Recombinant multi-species I36RA/ IL36RN/ FIL1 protein |
| Cytokine | GM-Tg-g-SE0627-Ag-1 | interleukin 36 receptor antagonist (IL36RN) protein |
| ORF Viral Vector | vGMLP004790 | human IL36RN Lentivirus particle |
| ORF Viral Vector | pGMLP004790 | human IL36RN Lentivirus plasmid |
Target information
| Target ID | GM-SE0627 |
| Target Name | IL36RN |
| Gene ID | 26525,54450,311783,705268,518514,100065154 |
| Gene Symbol and Synonyms | FIL1,FIL1(DELTA),FIL1D,Fil1delta,If36rn,Il-1h3,IL-36Ra,IL1F5,IL1HY1,IL1L1,IL1RP3,IL36RA,IL36RN,PSORP,PSORS14 |
| Uniprot Accession | Q9UBH0 |
| Uniprot Entry Name | I36RA_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000136695 |
| Target Classification | N/A |
The target: IL36RN, gene name: IL36RN, also named as FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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