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Anti-SLIB/ GHRH/ GHRF functional antibody
Anti-SLIB/ GHRH/ GHRF functional antibody for cell culture, ELISA & in-vivo assay
Go to GHRH/GHRH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0946-Ab-1/ GM-Tg-hg-SE0946-Ab-2 | Anti-Human GHRH monoclonal antibody | Human |
| GM-Tg-rg-SE0946-Ab-1/ GM-Tg-rg-SE0946-Ab-2 | Anti-Rat GHRH monoclonal antibody | Rat |
| GM-Tg-mg-SE0946-Ab-1/ GM-Tg-mg-SE0946-Ab-2 | Anti-Mouse GHRH monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0946-Ab-1/ GM-Tg-cynog-SE0946-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GHRH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0946-Ab-1/ GM-Tg-felg-SE0946-Ab-2 | Anti-Feline GHRH monoclonal antibody | Feline |
| GM-Tg-cang-SE0946-Ab-1/ GM-Tg-cang-SE0946-Ab-2 | Anti-Canine GHRH monoclonal antibody | Canine |
| GM-Tg-bovg-SE0946-Ab-1/ GM-Tg-bovg-SE0946-Ab-2 | Anti-Bovine GHRH monoclonal antibody | Bovine |
| GM-Tg-equg-SE0946-Ab-1/ GM-Tg-equg-SE0946-Ab-2 | Anti-Equine GHRH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0946-Ab-1/ GM-Tg-hg-SE0946-Ab-2; GM-Tg-rg-SE0946-Ab-1/ GM-Tg-rg-SE0946-Ab-2; GM-Tg-mg-SE0946-Ab-1/ GM-Tg-mg-SE0946-Ab-2; GM-Tg-cynog-SE0946-Ab-1/ GM-Tg-cynog-SE0946-Ab-2; GM-Tg-felg-SE0946-Ab-1/ GM-Tg-felg-SE0946-Ab-2; GM-Tg-cang-SE0946-Ab-1/ GM-Tg-cang-SE0946-Ab-2; GM-Tg-bovg-SE0946-Ab-1/ GM-Tg-bovg-SE0946-Ab-2; GM-Tg-equg-SE0946-Ab-1/ GM-Tg-equg-SE0946-Ab-2 |
| Products Name | Anti-GHRH monoclonal antibody |
| Format | mab |
| Target Name | GHRH |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GHRH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0946-Ag-1 | Recombinant multi-species SLIB/ GHRH/ GHRF protein |
| ORF Viral Vector | vGMLP000190 | human GHRH Lentivirus particle |
| ORF Viral Vector | pGMLP000190 | human GHRH Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001315 | mouse Ghrh Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001315 | mouse Ghrh Lentivirus particle |
Target information
| Target ID | GM-SE0946 |
| Target Name | GHRH |
| Gene ID | 2691,14601,29446,701284,485863,101101046,281191,111769907 |
| Gene Symbol and Synonyms | GHRF,GHRH,GRF,INN |
| Uniprot Accession | P01286,P09916,P63292 |
| Uniprot Entry Name | SLIB_HUMAN,SLIB_RAT,SLIB_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000118702 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: GHRH, gene name: GHRH, also named as GHRF, GRF, INN. This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
