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Anti-LFTY2/ LEFTY2/ EBAF functional antibody
Anti-LFTY2/ LEFTY2/ EBAF functional antibody for cell culture, ELISA & in-vivo assay
Go to LEFTY2/LEFTY2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1068-Ab-1/ GM-Tg-hg-SE1068-Ab-2 | Anti-Human LEFTY2 monoclonal antibody | Human |
| GM-Tg-rg-SE1068-Ab-1/ GM-Tg-rg-SE1068-Ab-2 | Anti-Rat LEFTY2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1068-Ab-1/ GM-Tg-mg-SE1068-Ab-2 | Anti-Mouse LEFTY2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1068-Ab-1/ GM-Tg-cynog-SE1068-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LEFTY2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1068-Ab-1/ GM-Tg-felg-SE1068-Ab-2 | Anti-Feline LEFTY2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1068-Ab-1/ GM-Tg-cang-SE1068-Ab-2 | Anti-Canine LEFTY2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1068-Ab-1/ GM-Tg-bovg-SE1068-Ab-2 | Anti-Bovine LEFTY2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1068-Ab-1/ GM-Tg-equg-SE1068-Ab-2 | Anti-Equine LEFTY2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1068-Ab-1/ GM-Tg-hg-SE1068-Ab-2; GM-Tg-rg-SE1068-Ab-1/ GM-Tg-rg-SE1068-Ab-2; GM-Tg-mg-SE1068-Ab-1/ GM-Tg-mg-SE1068-Ab-2; GM-Tg-cynog-SE1068-Ab-1/ GM-Tg-cynog-SE1068-Ab-2; GM-Tg-felg-SE1068-Ab-1/ GM-Tg-felg-SE1068-Ab-2; GM-Tg-cang-SE1068-Ab-1/ GM-Tg-cang-SE1068-Ab-2; GM-Tg-bovg-SE1068-Ab-1/ GM-Tg-bovg-SE1068-Ab-2; GM-Tg-equg-SE1068-Ab-1/ GM-Tg-equg-SE1068-Ab-2 |
| Products Name | Anti-LEFTY2 monoclonal antibody |
| Format | mab |
| Target Name | LEFTY2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LEFTY2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1068-Ag-1 | Recombinant multi-species LFTY2/ LEFTY2/ EBAF protein |
| ORF Viral Vector | vGMLP000602 | human LEFTY2 Lentivirus particle |
| ORF Viral Vector | pGMLP000602 | human LEFTY2 Lentivirus plasmid |
Target information
| Target ID | GM-SE1068 |
| Target Name | LEFTY2 |
| Gene ID | 7044,320202 |
| Gene Symbol and Synonyms | 6030463A22Rik,EBAF,LEFTA,Leftb,lefty-2,lefty-B,LEFTY2,LEFTYA,TGFB4 |
| Uniprot Accession | O00292 |
| Uniprot Entry Name | LFTY2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000143768 |
| Target Classification | N/A |
The target: LEFTY2, gene name: LEFTY2, also named as EBAF, LEFTA, LEFTYA, TGFB4. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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