- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-LSHB/ LHB/ CGB4 functional antibody
Anti-LSHB/ LHB/ CGB4 functional antibody for cell culture, ELISA & in-vivo assay
Go to LHB/LHB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1072-Ab-1/ GM-Tg-hg-SE1072-Ab-2 | Anti-Human LHB monoclonal antibody | Human |
| GM-Tg-rg-SE1072-Ab-1/ GM-Tg-rg-SE1072-Ab-2 | Anti-Rat LHB monoclonal antibody | Rat |
| GM-Tg-mg-SE1072-Ab-1/ GM-Tg-mg-SE1072-Ab-2 | Anti-Mouse LHB monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1072-Ab-1/ GM-Tg-cynog-SE1072-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LHB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1072-Ab-1/ GM-Tg-felg-SE1072-Ab-2 | Anti-Feline LHB monoclonal antibody | Feline |
| GM-Tg-cang-SE1072-Ab-1/ GM-Tg-cang-SE1072-Ab-2 | Anti-Canine LHB monoclonal antibody | Canine |
| GM-Tg-bovg-SE1072-Ab-1/ GM-Tg-bovg-SE1072-Ab-2 | Anti-Bovine LHB monoclonal antibody | Bovine |
| GM-Tg-equg-SE1072-Ab-1/ GM-Tg-equg-SE1072-Ab-2 | Anti-Equine LHB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1072-Ab-1/ GM-Tg-hg-SE1072-Ab-2; GM-Tg-rg-SE1072-Ab-1/ GM-Tg-rg-SE1072-Ab-2; GM-Tg-mg-SE1072-Ab-1/ GM-Tg-mg-SE1072-Ab-2; GM-Tg-cynog-SE1072-Ab-1/ GM-Tg-cynog-SE1072-Ab-2; GM-Tg-felg-SE1072-Ab-1/ GM-Tg-felg-SE1072-Ab-2; GM-Tg-cang-SE1072-Ab-1/ GM-Tg-cang-SE1072-Ab-2; GM-Tg-bovg-SE1072-Ab-1/ GM-Tg-bovg-SE1072-Ab-2; GM-Tg-equg-SE1072-Ab-1/ GM-Tg-equg-SE1072-Ab-2 |
| Products Name | Anti-LHB monoclonal antibody |
| Format | mab |
| Target Name | LHB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LHB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1072-Ag-1 | Recombinant multi-species LSHB/ LHB/ CGB4 protein |
| ORF Viral Vector | pGMLP004554 | human LHB Lentivirus plasmid |
| ORF Viral Vector | vGMLP004554 | human LHB Lentivirus particle |
| ORF Viral Vector | pGMLPm001287 | mouse Lhb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001287 | mouse Lhb Lentivirus particle |
Target information
| Target ID | GM-SE1072 |
| Target Name | LHB |
| Gene ID | 3972,16866,25329,100429401 |
| Gene Symbol and Synonyms | CGB4,Gm29035,HH23,LH,LH-B,LHB,LSH-B,LSH-beta |
| Uniprot Accession | P01229,P01230,P18842 |
| Uniprot Entry Name | LSHB_HUMAN,LSHB_RAT,LSHB_CANLF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Ovary Cancer, breast cancer |
| Gene Ensembl | ENSG00000104826 |
| Target Classification | N/A |
The target: LHB, gene name: LHB, also named as CGB4, HH23, LSH-B, LSH-beta. This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
