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Anti-REG1A/ ICRF/ P19 functional antibody
Anti-REG1A/ ICRF/ P19 functional antibody for cell culture, ELISA & in-vivo assay
Go to REG1A/REG1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1236-Ab-1/ GM-Tg-hg-SE1236-Ab-2 | Anti-Human REG1A monoclonal antibody | Human |
| GM-Tg-rg-SE1236-Ab-1/ GM-Tg-rg-SE1236-Ab-2 | Anti-Rat REG1A monoclonal antibody | Rat |
| GM-Tg-mg-SE1236-Ab-1/ GM-Tg-mg-SE1236-Ab-2 | Anti-Mouse REG1A monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1236-Ab-1/ GM-Tg-cynog-SE1236-Ab-2 | Anti-Cynomolgus/ Rhesus macaque REG1A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1236-Ab-1/ GM-Tg-felg-SE1236-Ab-2 | Anti-Feline REG1A monoclonal antibody | Feline |
| GM-Tg-cang-SE1236-Ab-1/ GM-Tg-cang-SE1236-Ab-2 | Anti-Canine REG1A monoclonal antibody | Canine |
| GM-Tg-bovg-SE1236-Ab-1/ GM-Tg-bovg-SE1236-Ab-2 | Anti-Bovine REG1A monoclonal antibody | Bovine |
| GM-Tg-equg-SE1236-Ab-1/ GM-Tg-equg-SE1236-Ab-2 | Anti-Equine REG1A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1236-Ab-1/ GM-Tg-hg-SE1236-Ab-2; GM-Tg-rg-SE1236-Ab-1/ GM-Tg-rg-SE1236-Ab-2; GM-Tg-mg-SE1236-Ab-1/ GM-Tg-mg-SE1236-Ab-2; GM-Tg-cynog-SE1236-Ab-1/ GM-Tg-cynog-SE1236-Ab-2; GM-Tg-felg-SE1236-Ab-1/ GM-Tg-felg-SE1236-Ab-2; GM-Tg-cang-SE1236-Ab-1/ GM-Tg-cang-SE1236-Ab-2; GM-Tg-bovg-SE1236-Ab-1/ GM-Tg-bovg-SE1236-Ab-2; GM-Tg-equg-SE1236-Ab-1/ GM-Tg-equg-SE1236-Ab-2 |
| Products Name | Anti-REG1A monoclonal antibody |
| Format | mab |
| Target Name | REG1A |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-REG1A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1236-Ag-1 | Recombinant multi-species REG1A/ ICRF/ P19 protein |
| ORF Viral Vector | vGMLP003861 | human REG1A Lentivirus particle |
| ORF Viral Vector | pGMLP003861 | human REG1A Lentivirus plasmid |
Target information
| Target ID | GM-SE1236 |
| Target Name | REG1A |
| Gene ID | 5967 |
| Gene Symbol and Synonyms | ICRF,P19,PSP,PSPS,PSPS1,PTP,REG,REG1A |
| Uniprot Accession | P05451 |
| Uniprot Entry Name | REG1A_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Pancreas Cancer, Other obstructive and reflux uropathy, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000115386 |
| Target Classification | N/A |
The target: REG1A, gene name: REG1A, also named as ICRF, P19, PSP, PSPS, PSPS1, PTP, REG. This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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