Anti-SFRP5/ SARP3 functional antibody

Anti-SFRP5/ SARP3 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SFRP5/SFRP5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1285-Ab-1/ GM-Tg-hg-SE1285-Ab-2Anti-Human SFRP5 monoclonal antibodyHuman
GM-Tg-rg-SE1285-Ab-1/ GM-Tg-rg-SE1285-Ab-2Anti-Rat SFRP5 monoclonal antibodyRat
GM-Tg-mg-SE1285-Ab-1/ GM-Tg-mg-SE1285-Ab-2Anti-Mouse SFRP5 monoclonal antibodyMouse
GM-Tg-cynog-SE1285-Ab-1/ GM-Tg-cynog-SE1285-Ab-2Anti-Cynomolgus/ Rhesus macaque SFRP5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1285-Ab-1/ GM-Tg-felg-SE1285-Ab-2Anti-Feline SFRP5 monoclonal antibodyFeline
GM-Tg-cang-SE1285-Ab-1/ GM-Tg-cang-SE1285-Ab-2Anti-Canine SFRP5 monoclonal antibodyCanine
GM-Tg-bovg-SE1285-Ab-1/ GM-Tg-bovg-SE1285-Ab-2Anti-Bovine SFRP5 monoclonal antibodyBovine
GM-Tg-equg-SE1285-Ab-1/ GM-Tg-equg-SE1285-Ab-2Anti-Equine SFRP5 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1285-Ab-1/ GM-Tg-hg-SE1285-Ab-2; GM-Tg-rg-SE1285-Ab-1/ GM-Tg-rg-SE1285-Ab-2;
GM-Tg-mg-SE1285-Ab-1/ GM-Tg-mg-SE1285-Ab-2; GM-Tg-cynog-SE1285-Ab-1/ GM-Tg-cynog-SE1285-Ab-2;
GM-Tg-felg-SE1285-Ab-1/ GM-Tg-felg-SE1285-Ab-2; GM-Tg-cang-SE1285-Ab-1/ GM-Tg-cang-SE1285-Ab-2;
GM-Tg-bovg-SE1285-Ab-1/ GM-Tg-bovg-SE1285-Ab-2; GM-Tg-equg-SE1285-Ab-1/ GM-Tg-equg-SE1285-Ab-2
Products NameAnti-SFRP5 monoclonal antibody
Formatmab
Target NameSFRP5
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SFRP5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1285-Ag-1Recombinant multi-species SFRP5/ SARP3 protein
    ORF Viral VectorvGMLP004521human SFRP5 Lentivirus particle
    ORF Viral VectorpGMLP004521human SFRP5 Lentivirus plasmid
    ORF Viral VectorpGMAAV000278house mouse Sfrp5 AAV plasmid
    ORF Viral VectorpGMLPm002147mouse Sfrp5 Lentivirus plasmid
    ORF Viral VectorvGMAAV000278house mouse Sfrp5 AAV particle
    ORF Viral VectorvGMLPm002147mouse Sfrp5 Lentivirus particle


    Target information

    Target IDGM-SE1285
    Target NameSFRP5
    Gene ID6425,54612,309377,707738,486826,101088696,282069,100070673
    Gene Symbol and SynonymsSARP3,SFRP5
    Uniprot AccessionQ5T4F7,Q9XSC1
    Uniprot Entry NameSFRP5_HUMAN,SFRP5_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseCancer
    Gene EnsemblENSG00000120057
    Target ClassificationTumor-associated antigen (TAA)

    The target: SFRP5, gene name: SFRP5, also named as SARP3. Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.