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Anti-TSHB/ TSH-B/ TSH-BETA functional antibody
Anti-TSHB/ TSH-B/ TSH-BETA functional antibody for cell culture, ELISA & in-vivo assay
Go to TSHB/TSHB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1348-Ab-1/ GM-Tg-hg-SE1348-Ab-2 | Anti-Human TSHB monoclonal antibody | Human |
| GM-Tg-rg-SE1348-Ab-1/ GM-Tg-rg-SE1348-Ab-2 | Anti-Rat TSHB monoclonal antibody | Rat |
| GM-Tg-mg-SE1348-Ab-1/ GM-Tg-mg-SE1348-Ab-2 | Anti-Mouse TSHB monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1348-Ab-1/ GM-Tg-cynog-SE1348-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TSHB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1348-Ab-1/ GM-Tg-felg-SE1348-Ab-2 | Anti-Feline TSHB monoclonal antibody | Feline |
| GM-Tg-cang-SE1348-Ab-1/ GM-Tg-cang-SE1348-Ab-2 | Anti-Canine TSHB monoclonal antibody | Canine |
| GM-Tg-bovg-SE1348-Ab-1/ GM-Tg-bovg-SE1348-Ab-2 | Anti-Bovine TSHB monoclonal antibody | Bovine |
| GM-Tg-equg-SE1348-Ab-1/ GM-Tg-equg-SE1348-Ab-2 | Anti-Equine TSHB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1348-Ab-1/ GM-Tg-hg-SE1348-Ab-2; GM-Tg-rg-SE1348-Ab-1/ GM-Tg-rg-SE1348-Ab-2; GM-Tg-mg-SE1348-Ab-1/ GM-Tg-mg-SE1348-Ab-2; GM-Tg-cynog-SE1348-Ab-1/ GM-Tg-cynog-SE1348-Ab-2; GM-Tg-felg-SE1348-Ab-1/ GM-Tg-felg-SE1348-Ab-2; GM-Tg-cang-SE1348-Ab-1/ GM-Tg-cang-SE1348-Ab-2; GM-Tg-bovg-SE1348-Ab-1/ GM-Tg-bovg-SE1348-Ab-2; GM-Tg-equg-SE1348-Ab-1/ GM-Tg-equg-SE1348-Ab-2 |
| Products Name | Anti-TSHB monoclonal antibody |
| Format | mab |
| Target Name | TSHB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TSHB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1348-Ag-1 | Recombinant multi-species TSHB/ TSH-B/ TSH-BETA protein |
| ORF Viral Vector | vGMLP002942 | human TSHB Lentivirus particle |
| ORF Viral Vector | pGMLP002942 | human TSHB Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000977 | mouse Tshb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000977 | mouse Tshb Lentivirus particle |
Target information
| Target ID | GM-SE1348 |
| Target Name | TSHB |
| Gene ID | 7252,22094,25653,709374,403973,554350,281552,100034188 |
| Gene Symbol and Synonyms | TSH-B,TSH-BETA,TSHB |
| Uniprot Accession | P01222,P04652,P54828,Q52R90,P01223,Q28376 |
| Uniprot Entry Name | TSHB_HUMAN,TSHB_RAT,TSHB_FELCA,TSHB_CANLF,TSHB_BOVIN,TSHB_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Diagnostics Biomarker |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000134200 |
| Target Classification | N/A |
The target: TSHB, gene name: TSHB, also named as TSH-B, TSH-BETA. The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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