Anti-ASPG/ AGA/ AGU functional antibody

Anti-ASPG/ AGA/ AGU functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to AGA/AGA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1405-Ab-1/ GM-Tg-hg-SE1405-Ab-2Anti-Human AGA monoclonal antibodyHuman
GM-Tg-rg-SE1405-Ab-1/ GM-Tg-rg-SE1405-Ab-2Anti-Rat AGA monoclonal antibodyRat
GM-Tg-mg-SE1405-Ab-1/ GM-Tg-mg-SE1405-Ab-2Anti-Mouse AGA monoclonal antibodyMouse
GM-Tg-cynog-SE1405-Ab-1/ GM-Tg-cynog-SE1405-Ab-2Anti-Cynomolgus/ Rhesus macaque AGA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1405-Ab-1/ GM-Tg-felg-SE1405-Ab-2Anti-Feline AGA monoclonal antibodyFeline
GM-Tg-cang-SE1405-Ab-1/ GM-Tg-cang-SE1405-Ab-2Anti-Canine AGA monoclonal antibodyCanine
GM-Tg-bovg-SE1405-Ab-1/ GM-Tg-bovg-SE1405-Ab-2Anti-Bovine AGA monoclonal antibodyBovine
GM-Tg-equg-SE1405-Ab-1/ GM-Tg-equg-SE1405-Ab-2Anti-Equine AGA monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1405-Ab-1/ GM-Tg-hg-SE1405-Ab-2; GM-Tg-rg-SE1405-Ab-1/ GM-Tg-rg-SE1405-Ab-2;
GM-Tg-mg-SE1405-Ab-1/ GM-Tg-mg-SE1405-Ab-2; GM-Tg-cynog-SE1405-Ab-1/ GM-Tg-cynog-SE1405-Ab-2;
GM-Tg-felg-SE1405-Ab-1/ GM-Tg-felg-SE1405-Ab-2; GM-Tg-cang-SE1405-Ab-1/ GM-Tg-cang-SE1405-Ab-2;
GM-Tg-bovg-SE1405-Ab-1/ GM-Tg-bovg-SE1405-Ab-2; GM-Tg-equg-SE1405-Ab-1/ GM-Tg-equg-SE1405-Ab-2
Products NameAnti-AGA monoclonal antibody
Formatmab
Target NameAGA
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AGA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1405-Ag-1Recombinant multi-species ASPG/ AGA/ AGU protein
    ORF Viral VectorvGMLP001236human AGA Lentivirus particle
    ORF Viral VectorpGMLP001236human AGA Lentivirus plasmid
    ORF Viral VectorpGMLPm002161mouse Aga Lentivirus plasmid
    ORF Viral VectorvGMLPm002161mouse Aga Lentivirus particle


    Target information

    Target IDGM-SE1405
    Target NameAGA
    Gene ID175,11593,290923,699740,475638,101086138,511345,100060636
    Gene Symbol and SynonymsAGA,AGU,ASRG,GA
    Uniprot AccessionP20933,P30919
    Uniprot Entry NameASPG_HUMAN,ASPG_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000038002
    Target ClassificationN/A

    The target: AGA, gene name: AGA, also named as AGU, ASRG, GA. This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.