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Anti-ASPG/ AGA/ AGU functional antibody
Anti-ASPG/ AGA/ AGU functional antibody for cell culture, ELISA & in-vivo assay
Go to AGA/AGA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1405-Ab-1/ GM-Tg-hg-SE1405-Ab-2 | Anti-Human AGA monoclonal antibody | Human |
| GM-Tg-rg-SE1405-Ab-1/ GM-Tg-rg-SE1405-Ab-2 | Anti-Rat AGA monoclonal antibody | Rat |
| GM-Tg-mg-SE1405-Ab-1/ GM-Tg-mg-SE1405-Ab-2 | Anti-Mouse AGA monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1405-Ab-1/ GM-Tg-cynog-SE1405-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AGA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1405-Ab-1/ GM-Tg-felg-SE1405-Ab-2 | Anti-Feline AGA monoclonal antibody | Feline |
| GM-Tg-cang-SE1405-Ab-1/ GM-Tg-cang-SE1405-Ab-2 | Anti-Canine AGA monoclonal antibody | Canine |
| GM-Tg-bovg-SE1405-Ab-1/ GM-Tg-bovg-SE1405-Ab-2 | Anti-Bovine AGA monoclonal antibody | Bovine |
| GM-Tg-equg-SE1405-Ab-1/ GM-Tg-equg-SE1405-Ab-2 | Anti-Equine AGA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1405-Ab-1/ GM-Tg-hg-SE1405-Ab-2; GM-Tg-rg-SE1405-Ab-1/ GM-Tg-rg-SE1405-Ab-2; GM-Tg-mg-SE1405-Ab-1/ GM-Tg-mg-SE1405-Ab-2; GM-Tg-cynog-SE1405-Ab-1/ GM-Tg-cynog-SE1405-Ab-2; GM-Tg-felg-SE1405-Ab-1/ GM-Tg-felg-SE1405-Ab-2; GM-Tg-cang-SE1405-Ab-1/ GM-Tg-cang-SE1405-Ab-2; GM-Tg-bovg-SE1405-Ab-1/ GM-Tg-bovg-SE1405-Ab-2; GM-Tg-equg-SE1405-Ab-1/ GM-Tg-equg-SE1405-Ab-2 |
| Products Name | Anti-AGA monoclonal antibody |
| Format | mab |
| Target Name | AGA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AGA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1405-Ag-1 | Recombinant multi-species ASPG/ AGA/ AGU protein |
| ORF Viral Vector | vGMLP001236 | human AGA Lentivirus particle |
| ORF Viral Vector | pGMLP001236 | human AGA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002161 | mouse Aga Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002161 | mouse Aga Lentivirus particle |
Target information
| Target ID | GM-SE1405 |
| Target Name | AGA |
| Gene ID | 175,11593,290923,699740,475638,101086138,511345,100060636 |
| Gene Symbol and Synonyms | AGA,AGU,ASRG,GA |
| Uniprot Accession | P20933,P30919 |
| Uniprot Entry Name | ASPG_HUMAN,ASPG_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000038002 |
| Target Classification | N/A |
The target: AGA, gene name: AGA, also named as AGU, ASRG, GA. This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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