Anti-RGCC/ C13orf15/ RGC-32 functional antibody

Anti-RGCC/ C13orf15/ RGC-32 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to RGCC/RGCC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1444-Ab-1/ GM-Tg-hg-SE1444-Ab-2Anti-Human RGCC monoclonal antibodyHuman
GM-Tg-rg-SE1444-Ab-1/ GM-Tg-rg-SE1444-Ab-2Anti-Rat RGCC monoclonal antibodyRat
GM-Tg-mg-SE1444-Ab-1/ GM-Tg-mg-SE1444-Ab-2Anti-Mouse RGCC monoclonal antibodyMouse
GM-Tg-cynog-SE1444-Ab-1/ GM-Tg-cynog-SE1444-Ab-2Anti-Cynomolgus/ Rhesus macaque RGCC monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1444-Ab-1/ GM-Tg-felg-SE1444-Ab-2Anti-Feline RGCC monoclonal antibodyFeline
GM-Tg-cang-SE1444-Ab-1/ GM-Tg-cang-SE1444-Ab-2Anti-Canine RGCC monoclonal antibodyCanine
GM-Tg-bovg-SE1444-Ab-1/ GM-Tg-bovg-SE1444-Ab-2Anti-Bovine RGCC monoclonal antibodyBovine
GM-Tg-equg-SE1444-Ab-1/ GM-Tg-equg-SE1444-Ab-2Anti-Equine RGCC monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1444-Ab-1/ GM-Tg-hg-SE1444-Ab-2; GM-Tg-rg-SE1444-Ab-1/ GM-Tg-rg-SE1444-Ab-2;
GM-Tg-mg-SE1444-Ab-1/ GM-Tg-mg-SE1444-Ab-2; GM-Tg-cynog-SE1444-Ab-1/ GM-Tg-cynog-SE1444-Ab-2;
GM-Tg-felg-SE1444-Ab-1/ GM-Tg-felg-SE1444-Ab-2; GM-Tg-cang-SE1444-Ab-1/ GM-Tg-cang-SE1444-Ab-2;
GM-Tg-bovg-SE1444-Ab-1/ GM-Tg-bovg-SE1444-Ab-2; GM-Tg-equg-SE1444-Ab-1/ GM-Tg-equg-SE1444-Ab-2
Products NameAnti-RGCC monoclonal antibody
Formatmab
Target NameRGCC
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RGCC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1444-Ag-1Recombinant multi-species RGCC/ C13orf15/ RGC-32 protein
    ORF Viral VectorvGMLP004954human Rgcc Lentivirus particle
    ORF Viral VectorpGMLP004954human Rgcc Lentivirus plasmid
    ORF Viral VectorpGMLPm000275mouse Rgcc Lentivirus plasmid
    ORF Viral VectorvGMLPm000275mouse Rgcc Lentivirus particle


    Target information

    Target IDGM-SE1444
    Target NameRGCC
    Gene ID28984,66214,117183,698962,609534,101090320,614348,100061031
    Gene Symbol and Synonyms1190002H23Rik,bA157L14.2,C12H13orf15,C13orf15,C17H13orf15,C22H13orf15,RGC-32,RGC32,RGCC
    Uniprot AccessionQ9H4X1,Q9Z2P4
    Uniprot Entry NameRGCC_HUMAN,RGCC_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000102760
    Target ClassificationN/A

    The target: RGCC, gene name: RGCC, also named as C13orf15, RGC-32, RGC32, bA157L14.2. This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.