Anti-DHFR monoclonal antibody

Pre-made anti-DHFR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to DHFR/DHFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T17345-Ab-1/ GM-Tg-hg-T17345-Ab-2Anti-Human DHFR monoclonal antibodyHuman
GM-Tg-rg-T17345-Ab-1/ GM-Tg-rg-T17345-Ab-2Anti-Rat DHFR monoclonal antibodyRat
GM-Tg-mg-T17345-Ab-1/ GM-Tg-mg-T17345-Ab-2Anti-Mouse DHFR monoclonal antibodyMouse
GM-Tg-cynog-T17345-Ab-1/ GM-Tg-cynog-T17345-Ab-2Anti-Cynomolgus/ Rhesus macaque DHFR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T17345-Ab-1/ GM-Tg-felg-T17345-Ab-2Anti-Feline DHFR monoclonal antibodyFeline
GM-Tg-cang-T17345-Ab-1/ GM-Tg-cang-T17345-Ab-2Anti-Canine DHFR monoclonal antibodyCanine
GM-Tg-bovg-T17345-Ab-1/ GM-Tg-bovg-T17345-Ab-2Anti-Bovine DHFR monoclonal antibodyBovine
GM-Tg-equg-T17345-Ab-1/ GM-Tg-equg-T17345-Ab-2Anti-Equine DHFR monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T17345-Ab-1/ GM-Tg-hg-T17345-Ab-2; GM-Tg-rg-T17345-Ab-1/ GM-Tg-rg-T17345-Ab-2;
GM-Tg-mg-T17345-Ab-1/ GM-Tg-mg-T17345-Ab-2; GM-Tg-cynog-T17345-Ab-1/ GM-Tg-cynog-T17345-Ab-2;
GM-Tg-felg-T17345-Ab-1/ GM-Tg-felg-T17345-Ab-2; GM-Tg-cang-T17345-Ab-1/ GM-Tg-cang-T17345-Ab-2;
GM-Tg-bovg-T17345-Ab-1/ GM-Tg-bovg-T17345-Ab-2; GM-Tg-equg-T17345-Ab-1/ GM-Tg-equg-T17345-Ab-2
Products NameAnti-DHFR monoclonal antibody
Formatmab
Target NameDHFR
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-DHFR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T17345-Ag-1Recombinant multi-species DYR/ DHFR/ DHFRP1 protein
    ORF Viral VectorvGMLP000510human DHFR Lentivirus particle
    ORF Viral VectorvGMAP000102Human DHFR Adenovirus particle
    ORF Viral VectorpGMAP000102Human DHFR Adenovirus plasmid
    ORF Viral VectorpGMLP000510human DHFR Lentivirus plasmid
    ORF Viral VectorpGMLPm000076mouse Dhfr Lentivirus plasmid
    ORF Viral VectorvGMLPm000076mouse Dhfr Lentivirus particle


    Target information

    Target IDGM-T17345
    Target NameDHFR
    Gene ID1719,13361,24312,711268,479165,101087964,508809,100073256
    Gene Symbol and Synonyms8430436I03Rik,DHFR,DHFR1,DHFRP1,DYR
    Uniprot AccessionP00374,Q920D2,P00376
    Uniprot Entry NameDYR_HUMAN,DYR_RAT,DYR_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000228716
    Target ClassificationTumor-associated antigen (TAA)

    The target: DHFR, gene name: DHFR, also named as DHFRP1, DYR. Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.