Picture loading failed.

Target products collectionGo to IRE1a/ERN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Cat No.: GM-Tg-hg-T17656-Ab

Pre-made anti-IRE1a monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-IRE1a mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

The target: IRE1a, gene name: ERN1, also named as IRE1, IRE1P, IRE1a, hIRE1p. This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017].

Order information


* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry

Catalog No.List Price (In USD)Discount Price (In USD)Qty (Quantity)Sum (In USD)
GM-Tg-hg-T17656-Ab-1-1mg51503090
GM-Tg-hg-T17656-Ab-1-10mgInquiryInquiry
GM-Tg-hg-T17656-Ab-1-100mgInquiryInquiry
GM-Tg-hg-T17656-Ab-2-1mg51503090
GM-Tg-hg-T17656-Ab-2-10mgInquiryInquiry
GM-Tg-hg-T17656-Ab-2-100mgInquiryInquiry
GM-Tg-hg-T17656-Ab-xmgInquiryInquiry
Shipping Cost:760.00
Total:



Description

Catalog No.GM-Tg-hg-T17656-Ab-1, GM-Tg-hg-T17656-Ab-2
Products Name Anti-IRE1a/ERN1 monoclonal antibody
Formatmab
Target NameIRE1a
Gene IDERN1
Gene NameERN1
Gene AliasIRE1, IRE1P, IRE1a, hIRE1p
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
Species ReactivityHuman(H)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-IRE1a monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.